Keywords: high/low temperature surface air cooler, thermal-moisture segmented handling, variable row number ratio, and energy-saving rate Abstract. The row number ratio between high temperature surface air cooler and low temperature one of segmented handling air-conditioning system has great impact on its performance. To study the variation of the system performance on different row number ratios, a performance prediction model of the segmented handling process is developed, and an experimental device including high/low temperature surface air coolers and high/low temperature water chillers is built up, analysis of the simulation and experiment of segmented handling air-conditioning system on three different row number ratios (2:2, 1:3, 3:1) under variable supply temperature of high temperature chilled water is studied. The results show that relative errors of performance parameters such as total heat exchange, energy-saving rate and dehumidification quantity between simulation and experiment are within 12%; The adjustable range of total heat exchange and dehumidification quantity of the system caused by chilled water temperature increasing from 7 to 19°C on 3:1 is bigger than on 2:2 and on 1:3 ,and the energy-saving rate of the system on 3:1 is the most when the inlet air dry-bulb temperature is 26°C; The energy-saving rate on 2:2 is equivalent to on 3:1 and the dehumidification ability on 2:2 is better than 3:1 when the part load of system is larger.