A rigid base is assumed in most seismic studies of liquid storage tanks. Additionally, recent studies have shown that permitting uplift can significantly reduce the damage to tanks. Uplift is the transient partial separation of the tank base from the supporting foundation. However, uplift of storage tanks is still not well studied and a rigid base is assumed in numerical studies. In this work, the simultaneous effect of uplift and a soil foundation are utilised to evaluate experimentally the effect of these two factors on the acceleration in the tank wall. A low-density polyethylene tank and a shake table were employed. Stochastically generated seismic excitation is employed based on the New Zealand design standard, NZS 1170.5, for medium soil, classification B. Three base conditions were considered: 1) fixed-base tank on a rigid support, 2) freebase tank on a rigid support and 3) free-base tank on a flexible support. To simulate the rigid support condition, the tank is resting on a steel plate rigidly attached to the shake table. A laminar box infilled with sand is utilised to represent a flexible soil condition. Results revealed that the highest acceleration at the tank top occurred when the tank is resting freely on a rigid supporting base. Furthermore, for this case the maximum uplift occurred at the same time as the maximum acceleration. However, for the case of a flexible support, the maximum acceleration occurred at the tank base and did not coincide with the time of maximum uplift. The maximum uplift occurred for a flexible supporting base and is not related to the maximum acceleration at the tank top. Thus, the distribution of the maximum acceleration, and hence uplift, depends significantly on the support condition.