A simpler potentiometric method for histamine assessment in blood sera

Pereira, Ana Rita; Araújo, Alberto N.; Montenegro, M.C.B.S.M.; Amorim, Célia G.

doi:10.1007/s00216-020-02597-6

Cited by 10 publications

(6 citation statements)

References 35 publications

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“…Amorim and coworkers recently reported a new histamine-selective electrode based on CB6 as ionophore and a polymeric membrane. 500 Moreover, 2-nitrophenyl octyl ether was used as a solvent mediator, and potassium tetrakis(4-chlorophenyl)borate functioned as anionic additive. The addition of multiwalled carbon nanotubes as electrical conductors in the membrane extended the lifetimes of the electrodes, shortened the response times, and enabled a detection limit of 100 nM for histamine.…”

Section: Chemosensors For Neurotransmittersmentioning

confidence: 99%

“…This circumstance makes its detection in blood or in food products important to identify potential risk factors. Amorim and coworkers recently reported a new histamine-selective electrode based on CB6 as ionophore and a polymeric membrane . Moreover, 2-nitrophenyl octyl ether was used as a solvent mediator, and potassium tetrakis(4-chlorophenyl)borate functioned as anionic additive.…”

Section: Neurotransmittersmentioning

confidence: 99%

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Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

et al. 2022

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Synthetic molecular probes, chemosensors, and nanosensors used in combination with innovative assay protocols hold great potential for the development of robust, low-cost, and fast-responding sensors that are applicable in biofluids (urine, blood, and saliva). Particularly, the development of sensors for metabolites, neurotransmitters, drugs, and inorganic ions is highly desirable due to a lack of suitable biosensors. In addition, the monitoring and analysis of metabolic and signaling networks in cells and organisms by optical probes and chemosensors is becoming increasingly important in molecular biology and medicine. Thus, new perspectives for personalized diagnostics, theranostics, and biochemical/ medical research will be unlocked when standing limitations of artificial binders and receptors are overcome. In this review, we survey synthetic sensing systems that have promising (future) application potential for the detection of small molecules, cations, and anions in aqueous media and biofluids. Special attention was given to sensing systems that provide a readily measurable optical signal through dynamic covalent chemistry, supramolecular host− guest interactions, or nanoparticles featuring plasmonic effects. This review shall also enable the reader to evaluate the current performance of molecular probes, chemosensors, and nanosensors in terms of sensitivity and selectivity with respect to practical requirement, and thereby inspiring new ideas for the development of further advanced systems.

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Section: Chemosensors For Neurotransmittersmentioning

confidence: 99%

Section: Neurotransmittersmentioning

confidence: 99%

Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

et al. 2022

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“…Furthermore, the utility of gold and silver nanoparticles not only facilitates interactions between sensing elements, but also enable an ultra-high sensitivity for CD44 detection ( Figure 7B,C ). Aptamer-based electrochemical supramolecular biosensor is another promising platform due to its advantages, such as high sensitivity and fast response ( Rivas et al, 2015 ; Yu et al, 2016a ; Pereira et al, 2020 ). Yu et al proposed a new strategy for using smart protein biogates in electrochemical detection of prion protein (PrP C ) ( Yu et al, 2015 ).…”

Section: Supramolecular Sensing With Electrochemical and Electrical Read-outsmentioning

confidence: 99%

Evolution of Supramolecular Systems Towards Next-Generation Biosensors

2021

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Supramolecular materials, which rely on dynamic non-covalent interactions, present a promising approach to advance the capabilities of currently available biosensors. The weak interactions between supramolecular monomers allow for adaptivity and responsiveness of supramolecular or self-assembling systems to external stimuli. In many cases, these characteristics improve the performance of recognition units, reporters, or signal transducers of biosensors. The facile methods for preparing supramolecular materials also allow for straightforward ways to combine them with other functional materials and create multicomponent sensors. To date, biosensors with supramolecular components are capable of not only detecting target analytes based on known ligand affinity or specific host-guest interactions, but can also be used for more complex structural detection such as chiral sensing. In this Review, we discuss the advancements in the area of biosensors, with a particular highlight on the designs of supramolecular materials employed in analytical applications over the years. We will first describe how different types of supramolecular components are currently used as recognition or reporter units for biosensors. The working mechanisms of detection and signal transduction by supramolecular systems will be presented, as well as the important hierarchical characteristics from the monomers to assemblies that contribute to selectivity and sensitivity. We will then examine how supramolecular materials are currently integrated in different types of biosensing platforms. Emerging trends and perspectives will be outlined, specifically for exploring new design and platforms that may bring supramolecular sensors a step closer towards practical use for multiplexed or differential sensing, higher throughput operations, real-time monitoring, reporting of biological function, as well as for environmental studies.

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“…Currently, polymeric membrane potentiometric sensors based on supramolecular macrocyclic hosts as receptors have been successfully applied to detect organic ions in clinical and environmental applications. [29][30][31][32][33][34][35] It should be noted, however, that these supramolecular macrocyclic receptors are usually selected empirically in the fabrication of potentiometric sensors. [36][37][38][39] The appropriate-ness of this empirical choice depends primarily on experiments based on trials and errors, which involve lengthy and time-consuming steps.…”

Section: Introductionmentioning

confidence: 99%