A Simple, Whole Blood Method for Assessment of Platelet Function

Allman‐Farinelli, Margaret; Bendall, Linda J.; Troy, Julian; Versluis, Cisca; Hall, David; Favaloro, Emmanuel J.; Berndt, Michael C.

doi:10.1016/s0049-3848(98)00030-9

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…Its function is not completely clear, although they were shown to mediate procoagulant platelet attachment to aggregates [58]. The release of alpha granules is believed to be produced by almost all platelet activators [59][60][61].…”

Section: Alpha Granule Releasementioning

confidence: 99%

Platelet functional responses and signalling: the molecular relationship. Part 1: responses.

Sveshnikova

Stepanyan

Panteleev

2021

SBPR

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Blood platelets are small anucleated cells whose main function is to form a plug upon vascular damage to stop bleeding. This role involves a number of functional responses induced by different agonists and coordinated by an intricate network of signal transduction pathways. Understanding this network is vital from both basic research point of view and for the purposes of drug target identification in thrombosis and hemostasis. This review series will focus on the regulation of platelet signalling, on tracking the molecular relationship between receptor activation and functional responses, and on the networking aspects of these pathways. The present paper, first one out of two, focuses on the description of platelet functional responses and of the conditions for their triggering.

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