A simple way to synthesize 3D hierarchical HAp porous microspheres with sustained drug release

Yang, Chen; Lin, Kaili; Chang, Jiang

doi:10.1016/j.ceramint.2015.05.064

Cited by 25 publications

(8 citation statements)

References 20 publications

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“…The FESEM images of the surface morphologies of PEO-treated as-printed implants before (a), and after the subsequent hydrothermal treatment at 250 • C for 2 h (b) and 4 h (c). and growth of HA crystals [39]. During the nucleation stage, the hydroxyl anions from the environment are adsorbed on the surface.…”

Section: Surface Characterization and Thickness Measurementsmentioning

confidence: 99%

Osteogenic and antibacterial surfaces on additively manufactured porous Ti-6Al-4V implants: Combining silver nanoparticles with hydrothermally synthesized HA nanocrystals

Fazel

Salimijazi

Shamanian

et al. 2021

Materials Science and Engineering: C

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The recently developed additively manufacturing techniques have enabled the fabrication of porous biomaterials that mimic the characteristics of the native bone, thereby avoiding stress shielding and facilitating bony ingrowth. However, aseptic loosening and bacterial infection, as the leading causes of implant failure, need to be further addressed through surface biofunctionalization. Here, we used a combination of (1) plasma electrolytic oxidation (PEO) using Ca-, P-, and silver nanoparticle-rich electrolytes and (2) post-PEO hydrothermal treatments (HT) to furnish additively manufactured Ti-6Al-4V porous implants with a multi-functional surface. The applied HT led to the formation of hydroxyapatite (HA) nanocrystals throughout the oxide layer. This process was controlled by the supersaturation of Ca 2+ and PO 4 3− during the hydrothermal process. Initially, the high local supersaturation resulted in homogenous nucleation of spindle-like nanocrystals throughout the surface. As the process continued, the depletion of reactant ions in the outermost surface layer led to a remarkable decrease in the supersaturation degrees. High aspect-ratio nanorods and hexagonal nanopillars were, therefore, created. The unique hierarchical structure of the microporous PEO layer (pore size < 3 μm) and spindle-like HA nanocrystals (<150 nm) on the surface of macro-porous additively manufactured Ti-6Al-4V implants provided a favorable substrate for the anchorage of cytoplasmic extensions assisting cell attachment and migration on the surface. The results of our in vitro assays clearly showed the important benefits of the HT and the spindle-like HA nanocrystals including a significantly stronger and much more sustained antibacterial activity, significantly higher levels of pre-osteoblasts metabolic activity, and significantly higher levels of alkaline phosphatase activity as compared to similar PEO-treated implants lacking the HT.

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Section: Surface Characterization and Thickness Measurementsmentioning

confidence: 99%

Osteogenic and antibacterial surfaces on additively manufactured porous Ti-6Al-4V implants: Combining silver nanoparticles with hydrothermally synthesized HA nanocrystals

Fazel

Salimijazi

Shamanian

et al. 2021

Materials Science and Engineering: C

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“…The hydrogen bonds induced O–H stretching bands are noticed at 2364 and 2855 cm −1 , which indicates the presence of hydrogen bonds in the CaHPO 4 structure 43 . A peak at ~868 cm −1 is attributed to the characteristic bands of HPO 4 2− , which identifies deficient of calcium and nonstoichiometric structure, such as CaHPO 4 43,44 . Similarly, peaks in between 1389 and 1426 cm −1 are due to carbonate groups (CO 3 2− ) and broad peaks at 3454 cm − 1, 1587 cm −1 are attributed to OH − stretching and OH bending respectively 12 .…”

Section: Resultsmentioning

confidence: 90%

“…The intense characteristic peaks at 585 and 1055 cm −1 are ascribed to phosphate groups (PO 4 3− ). The hydrogen bonds induced O–H stretching bands are noticed at 2364 and 2855 cm −1 , which indicates the presence of hydrogen bonds in the CaHPO 4 structure 43 . A peak at ~868 cm −1 is attributed to the characteristic bands of HPO 4 2− , which identifies deficient of calcium and nonstoichiometric structure, such as CaHPO 4 43,44 .…”

Section: Resultsmentioning

confidence: 93%

Effect of Fe³⁺ substitution on the structural modification and band structure modulated UV absorption of hydroxyapatite

Hadagalli

Shenoy

Shakya

et al. 2021

Int J Applied Ceramic Tech

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The effect of Fe3+ ionic substitution in hydroxyapatite (Ca10‐xFex(PO4)6(OH)2) was studied using structural modifications, resulting in an improvement in UV absorption through a tailored optical band structure. Ca2+ of HA being larger compared to Fe3+ contributes to the shrinkage of the lattice. Undoped HA has a peak at 1085 cm−1 (ʋ3 PO43−) which is shifted to 1033 cm−1 for Fe‐HA, because of the perturbation in HA structure. An improvement of UV absorption in the entire UVA and UVB range with an increase in Fe content because of a decrease in bandgap from 5.9 eV to 2.1 eV with undoped and doped HA. Theoretically obtained band gap and optical behaviour of the systems are well correlated with the experimental findings. Moreover, the use of marine biowaste from cuttlefish bone, as the source of HA; low cost and promising UV absorption can have a potential application as UV protective sunscreen filters.

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“…Moreover, other characteristic bands of β-TCP at 1035, 1075, and 1116 cm –1 possibly stay under more distinct band at 1126 cm –1 after phosphoric acid addition. New bands appearing at 1348, 1403, 1646, and 2862 cm –1 (Figure S5a) are correlated with CaHPO 4 molecule indicating the interaction between phosphoric acid and β-TCP . Additionally, the features located at 593 and 601 cm –1 in the FTIR spectrum of β-TCP (Figure S5b) disappear with phosphoric acid treatment.…”

Section: Resultsmentioning

confidence: 94%

Effect of Silane A-174 Modifications in the Structure, Chemistry, and Compressive Strength of PLA-HAP and PLA-β-TCP Biocomposites: Toward the Design of Polymer–Ceramic Implants with High Performance

Oner

Alakent

Soyer-Uzun

2021

ACS Appl. Polym. Mater.

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The effect of silane A-174 (3-(trimethoxysilyl)propyl methacrylate (methacryloxypropyl trimethoxysilane)) modifications of the ceramic surface on the structural characteristics and mechanical performance of hydroxyapatite (HAP)−polylactic acid (PLA) and β-tricalcium phosphate (β-TCP)−PLA composite systems was investigated employing a combination of Fourier transform infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), compressive strength measurements, and statistical models constructed via projection to latent structures (PLS) analysis. The composites were synthesized by solvent casting method at ambient conditions employing ceramic/PLA ratios of 60/40 and 50/ 50, and silane A-174 percentages of 0, 1, and 3 wt %. Peak positions of O 1s, Ca 2p, P 2p, Si 2p, and C 1s in XP spectra of ceramics, surface-modified ceramics, and the corresponding composites and compressive strength values were used as the predictors and response variables in PLS models. It was found that Ca 2p, P 2p, and Si 2p binding energies of the ceramic component employed in composite synthesis played the most significant role in determining compressive strength. PLA-HAP composite with a ceramic/PLA ratio of 50/50, synthesized employing 3 wt % silane A-174 treated HAP (HAP50PLA50Si3), resulted in enhancement of the compressive strength up to 365 MPa, which is the highest compressive strength value reported in the literature to the best of our knowledge. Additional P 2p, Ca 2p, and C 1s features positioned at 129.64, 350.08, and 280.74 eV in the XP spectra of this specimen together with significant shifts of Si 2p and C 1s bands toward lower binding energies and polymer-bridge-like surface characteristics signaled improved polymer−ceramic interaction in this composite. Attaining mechanical performance comparable with and even higher than that of cortical bone upon silane A-174 modifications might provide opportunities for clinical applications toward developing bioresorbable PLA-HAP-based implants that can be employed in load-bearing applications such as knee and hip replacements.

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A simple way to synthesize 3D hierarchical HAp porous microspheres with sustained drug release

Cited by 25 publications

References 20 publications

Osteogenic and antibacterial surfaces on additively manufactured porous Ti-6Al-4V implants: Combining silver nanoparticles with hydrothermally synthesized HA nanocrystals

Osteogenic and antibacterial surfaces on additively manufactured porous Ti-6Al-4V implants: Combining silver nanoparticles with hydrothermally synthesized HA nanocrystals

Effect of Fe³⁺ substitution on the structural modification and band structure modulated UV absorption of hydroxyapatite

Effect of Silane A-174 Modifications in the Structure, Chemistry, and Compressive Strength of PLA-HAP and PLA-β-TCP Biocomposites: Toward the Design of Polymer–Ceramic Implants with High Performance

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A simple way to synthesize 3D hierarchical HAp porous microspheres with sustained drug release

Cited by 25 publications

References 20 publications

Osteogenic and antibacterial surfaces on additively manufactured porous Ti-6Al-4V implants: Combining silver nanoparticles with hydrothermally synthesized HA nanocrystals

Osteogenic and antibacterial surfaces on additively manufactured porous Ti-6Al-4V implants: Combining silver nanoparticles with hydrothermally synthesized HA nanocrystals

Effect of Fe3+ substitution on the structural modification and band structure modulated UV absorption of hydroxyapatite

Effect of Silane A-174 Modifications in the Structure, Chemistry, and Compressive Strength of PLA-HAP and PLA-β-TCP Biocomposites: Toward the Design of Polymer–Ceramic Implants with High Performance

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Effect of Fe³⁺ substitution on the structural modification and band structure modulated UV absorption of hydroxyapatite