A simple tool for the synchronous differentiation of human induced pluripotent stem cells into pancreatic progenitors
Mee‐Hae Kim,
Naruchit Thanuthanakhun,
Masahiro Kino‐oka
Abstract:Efficient differentiation of human induced pluripotent stem cells (hiPSCs) into functional pancreatic cells holds great promise for diabetes research and treatment. However, a robust culture strategy for producing pancreatic progenitors with high homogeneity is lacking. Here, we established a simple differentiation strategy for generating synchronous iPSC‐derived pancreatic progenitors via a two‐step method of sequential cell synchronization using botulinum hemagglutinin (HA), an E‐cadherin function‐blocking a… Show more
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