A simple synthesis of trisubstituted quinolines through transesterification

Abstract

An efficient and simple method has been reported for the synthesis of 2,3,4‐trisubstituted quinolines through zwitterion intermediate under reflux condition in presence of sulfuric acid. The formed dicarboxylate subsequently undergoes transesterification in various alcohols with good yields. Most of the synthesized compounds are newly reported characterized by spectroscopic method. J. Heterocyclic Chem., (2011).

A facile synthesis and antibacterial activity of novel pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides

“…Esterification of different carboxylic acids lead to the correspondent ethyl ester (2a-e) and further hydrazineloysed yielded the hydrazides (3a-e). 2,3,4-trisubstituted quinolines (6a-d) were synthesized from different aromatic amino ketones 4a,b and dialkylacetylenedicarboxylate 5a,b in ethanol as reported (25). The dicarboxyquinoline derivatives 7a,b were prepared from the corresponding quinolinedicarboxylates 6a-d by alkaline hydrolysis, which was acidified with 1:1 HCl at low temperature (26).…”

Contemporary development in sequential Knoevenagel, Michael addition multicomponent reaction for the synthesis of 4-Aryl-5-oxo-5H-indeno[1,2-b]pyridine-3-carbonitrile

“…Thus, inspired by these fascinating aspects and in continuation of our efforts [35][36][37][38][39] to prepare vital heterocyclic molecules, herewith we put forth a highly proficient, less toxic method by utilizing a 1,3-dicarbonyl compound in multicomponent pattern.…”