A Simple Synthesis, of Some Novel Bi-Thiazoles as Anti-Tumor Agents

Abstract

A series of novel bi-thiazoles was synthesized by reaction of 2-(1-(2-(2-(1-(4-fluorophenyl)ethylidene)hydrazinyl)-4-methylthiazol-5-yl)ethylidene) hydrazine-1-carbothioamide 3 with a variety of hydrazonoyl chloride derivatives 4a-d, and 7 a-d affording 6a-d and 9a-d respectively in dioxane in the presence of triethyl amine as a base. Also, hydrazine-1-carbothioamide 3 reacts with substituted phenacyl bromide derivatives 10 a-d yielding 12a-d in appropriate reaction conditions. The mechanisms of the titled reactions were discussed. Structural assignments were based on spectroscopic methods (NMR, FTIR, MS). The new compounds were tested in vitro for their were subjected to in vitro anticancer screening against human hepatocellular carcinoma (HCT-116), (HepG-2) and the results showed that compounds 6a, 6d, 9a, 9c and 12a have promising activities compared with cisplatin reference drug.

Knowledge, Attitudes and Practices of Colorectal Cancer Screening in Morocco

“…Over 80% of participants agreed that diagnosing CRC at an early stage can improve, which is a good sign to help motivate people who implement screening programs. This was consistent with studies previously reported in Pakistan [10] , Saudi Arabia [12] and Italy [23] . It was observed that the most common preventive practice was reducing alcohol consumption and tobacco consumption (77%), which is consistent with the results reported in the literature in China (84%) and Pakistan (69%) [10,11] .…”

“…This was consistent with studies previously reported in Pakistan [10] , Saudi Arabia [12] and Italy [23] . It was observed that the most common preventive practice was reducing alcohol consumption and tobacco consumption (77%), which is consistent with the results reported in the literature in China (84%) and Pakistan (69%) [10,11] . Our study also showed an overall relationship between knowledge, attitude and screening practice towards CRC like most previous studies [14,18,22,25] .…”

“…These results provided important information to facilitate participation in the screening program for CRC and other public policies for the prevention of CRC and other cancers. In this study, the level of overall knowledge (including that of risk factors and the warning signs of CRC) of the participants was 39%, this rate is lower than what was reported in Pakistan, China, Saudi Arabia and Bahrain where the knowledge level of the sample was respectively (44.8%, 63.1%, 66.4%, 56%) [10][11][12][13] . In addition, while participants had relatively good knowledge of risk factors, they had less knowledge of warning signs and screening methods.…”