A simple surface biofunctionalization strategy to inhibit the biofilm formation by Staphylococcus aureus on solid substrates

Martin, María Laura; Dassie, Sergio Alberto; Valenti, Laura E.; Giacomelli, Carla E.

doi:10.1016/j.colsurfb.2019.110432

Cited by 7 publications

(4 citation statements)

References 62 publications

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“…Studies of bacterial biofilm formation on non-living surfaces, of relevance for persistent infections through medical devices and implants, have been gaining more attention in the last 15 years ( Macleod and Stickler, 2007 ; Monds and O'Toole, 2009 ; Kania et al., 2010 ; Krzysciak et al., 2014 ; Martin et al., 2019 ) and show that biofilm formation, due to its organization and changes in bacterial phenotypes, is a major cause of antibiotic resistance ( Chao et al., 2014 ; Nirwati et al., 2019 )…”

Section: Biofilm Formation and Function: An Overviewmentioning

confidence: 99%

Klebsiella pneumoniae Biofilms and Their Role in Disease Pathogenesis

Guerra

Destro

Vieira

et al. 2022

Front. Cell. Infect. Microbiol.

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The ability to form biofilms is a crucial virulence trait for several microorganisms, including Klebsiella pneumoniae – a Gram-negative encapsulated bacterium often associated with nosocomial infections. It is estimated that 65-80% of bacterial infections are biofilm related. Biofilms are complex bacterial communities composed of one or more species encased in an extracellular matrix made of proteins, carbohydrates and genetic material derived from the bacteria themselves as well as from the host. Bacteria in the biofilm are shielded from immune responses and antibiotics. The present review discusses the characteristics of K. pneumoniae biofilms, factors affecting biofilm development, and their contribution to infections. We also explore different model systems designed to study biofilm formation in this species. A great number of factors contribute to biofilm establishment and maintenance in K. pneumoniae, which highlights the importance of this mechanism for the bacterial fitness. Some of these molecules could be used in future vaccines against this bacterium. However, there is still a lack of in vivo models to evaluate the contribution of biofilm development to disease pathogenesis. With that in mind, the combination of different methodologies has great potential to provide a more detailed scenario that more accurately reflects the steps and progression of natural infection.

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Section: Biofilm Formation and Function: An Overviewmentioning

confidence: 99%

Klebsiella pneumoniae Biofilms and Their Role in Disease Pathogenesis

Guerra

Destro

Vieira

et al. 2022

Front. Cell. Infect. Microbiol.

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“…Biofilms not only serve as incubator for the continuous reproduction of pathogenic bacteria but also help them adhere better to biological and abiotic surfaces. While also effectively resisting the action of antibiotics, this make the infection of pathogenic bacteria difficult to be eradicated (Guerra et al, 2022; Martín et al, 2019). In recent years, many genes have been shown to directly or indirectly regulate the formation of bacterial biofilms (Solomon et al, 2005; Vuotto et al, 2017; Zhang, Kang, et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Contribution of flagellar cap gene in virulence and pathogenicity of Aeromonas veronii

Cheng

Zhao

Jiang

et al. 2022

Journal of Fish Diseases

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Aeromonas veronii is an important zoonotic and aquatic pathogen that causes a number of illnesses in both humans and animals. It is related to gastroenteritis, skin and soft tissue infections and bacteremia in humans, as well as causing significant economic losses in aquaculture owing to fish sepsis. Here, we constructed the flagellar cap gene (fliD) mutant strain of A. veronii by suicide plasmid‐mediated homologous recombination system and analysed its characteristics. It was found that the deletion of fliD had no effect on growth and biochemical properties and could be inherited stably. However, the motility of A. veronii ΔfliD was significantly reduced, the flagellum was defective and the biofilm formation was attenuated compared with that of A. veronii wild‐type strain. In vivo experiments revealed that the colonization capacity of ΔfliD was significantly lower than that of the wild‐type strain in the period of first 24 h, and the median lethal dose (LD50) was 56 times higher than that of the wild‐type strain. The Cyprinus carpio infected with the wild‐type strain indicated faster death speed and more severe clinical signs compared to ΔfliD strain. These results suggest that fliD is closely related to the virulence of A. veronii and plays an important role in pathogenicity, providing the foundation for pathogenic mechanism studies of A. veronii.

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“…Surfaces that have been coated with albumin could lead to low bacterial adhesion. 17 , 18 Ovalbumin used in this study could serve as a representative protein ingredient in food.…”

Section: Introductionmentioning

confidence: 99%

“…It could chelate heavy metals and trap them within sulfhydryl bonds and could reduce the absorption of metal ions into the digestive system and stop poisoning. Surfaces that have been coated with albumin could lead to low bacterial adhesion. , Ovalbumin used in this study could serve as a representative protein ingredient in food.…”

Section: Introductionmentioning

confidence: 99%

Corrosion Behavior and In Vitro Cytotoxicity of Ni–Ti and Stainless Steel Arch Wires Exposed to Lysozyme, Ovalbumin, and Bovine Serum Albumin

Zhang

Chen

et al. 2020

ACS Omega

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In this study, the tendency and mechanisms by which protein and mechanical loads contribute to corrosion were determined by exposing Ni–Ti and stainless steel arch wires under varying mechanical loads to artificial saliva containing different types of protein (lysozyme, ovalbumin, and bovine serum albumin). The corrosion behavior and in vitro cytotoxicity results show that exposure to both protein and mechanical stress significantly decreased the corrosion resistance of stainless steel and increased the release of toxic corrosion products. Adding protein inhibited the corrosion of Ni–Ti, but the mechanical loads counteracted this effect. Even proteins containing the same types of amino acids had different effects on the corrosion resistance of the same alloy. The effect of protein or stress, or their combination, should be considered in the application of metal medical materials.

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A simple surface biofunctionalization strategy to inhibit the biofilm formation by Staphylococcus aureus on solid substrates

Cited by 7 publications

References 62 publications

Klebsiella pneumoniae Biofilms and Their Role in Disease Pathogenesis

Klebsiella pneumoniae Biofilms and Their Role in Disease Pathogenesis

Contribution of flagellar cap gene in virulence and pathogenicity of Aeromonas veronii

Corrosion Behavior and In Vitro Cytotoxicity of Ni–Ti and Stainless Steel Arch Wires Exposed to Lysozyme, Ovalbumin, and Bovine Serum Albumin

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