A simple strategy for the efficient design of mitochondria-targeting NIR-II phototheranostics

Abstract

The pursuit of phototheranostic with near-infrared II (NIR-II) emission, high photothermal conversion efficiency (PCE) and robust reactive oxygen species (ROS) generation in aggregate is always in high demand but remains...

Bridging Smart Nanosystems with Clinically Relevant Models and Advanced Imaging for Precision Drug Delivery

“…Meanwhile, advanced AIE techniques have also been developed for targeted organelle imaging. With functional units, AIEgens are designed to specifically interact with cytoplasm membrane, [ 248 ] lysosome, [ 249 ] mitochondria, [ 250 ] nucleus, [ 251 ] and so on, which brings sub‐cellular information and provides access to explore the fate of NDC after the transmembrane displacement. Despite the relatively rapid developing progress of the AIE techniques in imaging NP‐cell interaction, there are also challenges to be considered.…”

A type I and type II chemical biology toolbox to overcome the hypoxic tumour microenvironment for photodynamic therapy

“…The TDTN + facilitates brain imaging with enhanced fluorescence and exhibits a potent anti-tumor effect. 52 Lastly, Zheng et al successfully designed and synthesized three photosensitizers for PDT, with the specific incorporation of a biotin moiety to enhance tumor-targeting capabilities (Fig. 10c).…”

Small molecules and conjugates as theranostic agents

“…3G ). 63 The AIEgen was equipped with a benzobisthiadiazole and a triphenylamine moiety as acceptor and donor units, respectively, with long alkyl chains that hamper π–π interactions. It also included a cationic trimethylamonium unit for mitochondrial localization.…”