A simple specific titration method for serum calcium

Baron, D N; Bell, Joyce L.

doi:10.1016/0009-8981(57)90010-4

Cited by 35 publications

(13 citation statements)

References 4 publications

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“…The level of serum calcium when estimated by the E.D.T.A. method of Baron and Bell (1957) is lower than that Group obtained using other methods. Twenty-two of the patients who had had partial gastrectomy were further investigated by iliac crest bone biopsy, the calcium infusion test (Finlay, Nordin, and Fraser, 1956), and faecal fat estimations (van de Kamer, Huinink, and Weyers, 1949).…”

Section: Patients Studiedcontrasting

confidence: 66%

“…The sum of the dorsal score and lumbar score was called the 'spinal score' and we have arbitrarily defined spinal rarefaction as a spinal score of 160 or less (Deller and Begley, 1963). BIOCHEMISTRY One hundred patients after partial gastrectomy and 50 control subjects had blood taken for the estimation of serum calcium (Baron and Bell, 1957), phosphate (Fiske and Subbarow, 1925), and alkaline phosphatase (Marsh, Fingerhut, and Kirsch, 1959). The level of serum calcium when estimated by the E.D.T.A.…”

Section: Patients Studiedmentioning

confidence: 99%

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Metabolic effects of partial gastrectomy with special reference to calcium and folic acid: Part I Changes in calcium metabolism and the bones

Deller¹,

Begley²,

Edwards³

et al. 1964

Gut

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Section: Patients Studiedcontrasting

confidence: 66%

Section: Patients Studiedmentioning

confidence: 99%

Metabolic effects of partial gastrectomy with special reference to calcium and folic acid: Part I Changes in calcium metabolism and the bones

Deller¹,

Begley²,

Edwards³

et al. 1964

Gut

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“…At first a modified Tisdall method was used (Clark and Collip, 1925). Later estimations were made by titration against sodium edetate, with calcein-thymol-phthalein indicator, under a Wood's ultra-violet lamp (Baron and Bell, 1957). The two methods gave closely similar results in our hands.…”

Section: Patients Materials and Methodssupporting

confidence: 59%

The parathyroids, calcium and gastric secretion in man and the dog

Ward¹,

Adesola²,

Welbourn³

1964

Gut

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EDITORIAL SYNOPSIS The possible relationship between hyperparathyroidism and peptic ulcer has stimulated renewed interest in the relationship between calcium and gastric secretion. This study shows that in patients with primary hyperparathyroidism the basal secretion of acid was raised but the augmented histamine secretion was essentially normal. The basal secretion was lowered by parathyroidectomy. Studies in dogs shows a different pattern of gastric secretory response.A possible relationship between the parathyroid glands and gastric secretion was suggested nearly 50 years ago in experiments with innervated (Pavlov) gastric pouches. Keeton (1914) found that parathyroidectomy reduced secretion in the cat, and Rogers, Rahe, Fawcett, and Hackett (1915) observed that a crude extract of parathyroid tissue caused an increase in secretion in the dog. Several others have studied the problem from time to time, while today many are interested in it because of the recognition that peptic, and especially duodenal, ulceration is a frequent feature of both primary hyperparathyroidism and the syndrome of multiple endocrine adenopathy in man (Welbourn and Ward, 1962 Parathyroidectomy (partial or total and usually combined with thyroidectomy) has always been found to reduce the secretion of acid and of pepsin in animals, and subsequent injections of calcium salts have restored it (Keeton, 1914;Chang and Sloan, 1927). Here, however, it is difficult to distinguish between the separate influences of the thyroid and the parathyroid glands, even when thyroid substitution therapy is provided, for gastric secretion is reduced by an excess and possibly by a deficiency of thyroxine (Nasset and Goldsmith, 1961). However, in a patient with idiopathic hypoparathyroidism studied very thoroughly by Donegan and Spiro (1960) free acid was completely absent and the concentration of pepsin was very low in the basal juice. An infusion of calcium gluconate and an injection of parathormone both restored secretion rapidly for short periods of time. Prolonged therapy with vitamin D and calcium maintained the secretion of acid and of pepsin at normal levels. Low concentrations of acid in the gastric juice have also been found in infants with hypocalcaemic tetany and restoration of the serum calcium concentration has increased the acidity (Babbott, Johnston, and Haskins, 1923). In both these studies the critical level of serum calcium, at which gastric secretion was restored, was about 7 0 to 7 5 mg. per 100 ml. Parathyroidectomy in patients with primary hyperparathyroidism has not been found to produce any consistent change in secretion (Donegan and Spiro, 1960

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“…Na, K, C02, Cl, urea and glucose were done with an AutoAnalyser (Technicon), glucose being determined by the glucose oxidase method. Serum calcium was measured by a modification of the method of Baron and Bell (7) by use plasmocorinth B as indicator. Plasma fibrinogen was measured by the method of Nilsson and Olow (8).…”

Section: Introductionmentioning

confidence: 99%

Toxemia of pregnancy in sheep: a clinical, physiological, and pathological study

Ferris¹,

Herdson²,

Dunnill³

et al. 1969

J. Clin. Invest.

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A B S T R A C T Toxemia was induced in 13 of 20 pregnant ewes by the stress of a change in environment and food deprivation late in pregnancy. Of the toxemic ewes, eight developed prominent neurological findings with convulsions, motor weakness, and blindness, whereas five ewes developed azotemia without neurological signs. Proteinuria and azotemia occurred in all but one of the toxemic animals. Seven animals did not develop clinical or laboratory evidence of toxemia. Hypertension did not occur with the onset of toxemia but all toxemic animals showed glomerular changes by light and electron microscopy. These abnormalities, which were similar to those seen in human preeclampsia, included endothelial cell swelling, focal reduplication of the basement membrane, and fusion of the epithelial cell foot processes. The toxemia could not be attributed to changes in hematocrit, plasma glucose, Na, Cl, C02, K, Ca, fibrinogen, arterial pH, lactate, or pyruvate concentrations. Cardiac output fell only in ewes with prominent neurological signs. Plasma renin rose strikingly in animals developing toxemia, without change in substrate concentration. In contrast to human and other species, sheep uterus and amniotic fluid contained no detectable quantities of renin.Thus in response to stress the pregnant ewe develops a toxemia which in the absence of hypertension has clinical and pathological similarities to human preeclampsia.

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A simple specific titration method for serum calcium

Cited by 35 publications

References 4 publications

Metabolic effects of partial gastrectomy with special reference to calcium and folic acid: Part I Changes in calcium metabolism and the bones

Metabolic effects of partial gastrectomy with special reference to calcium and folic acid: Part I Changes in calcium metabolism and the bones

The parathyroids, calcium and gastric secretion in man and the dog

Toxemia of pregnancy in sheep: a clinical, physiological, and pathological study

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