A Simple Small Molecule with Synergistic Passive and Active Dual-Targeting Effects for Imaging-Guided Photothermal Cancer Therapy

Mu, Xueluer; Tang, Ying; Wu, Feng; Ma, Huihui; Huang, S.W.; Liang, Mingchen; Yang, Junyan; Lu, Yingxi; Zhou, Xianfeng; Li, Zhibo

doi:10.1021/acsami.1c11798

Cited by 15 publications

(7 citation statements)

References 42 publications

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“…Optical imaging is an indispensable component of molecular imaging [ 184 ]. In recent years, the benefits of optical imaging, such as high sensitivity, great cost-effectiveness, nonionizing effects, and real-time imaging capabilities, have attracted much attention in various studies of in vivo and in vitro systems [ 185 ].…”

Section: Nanozymes For Molecular Imagingmentioning

confidence: 99%

Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges

et al. 2023

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New nanotechnologies for imaging molecules are widely being applied to visualize the expression of specific molecules (e.g., ions, biomarkers) for disease diagnosis. Among various nanoplatforms, nanozymes, which exhibit enzyme-like catalytic activities in vivo, have gained tremendously increasing attention in molecular imaging due to their unique properties such as diverse enzyme-mimicking activities, excellent biocompatibility, ease of surface tenability, and low cost. In addition, by integrating different nanoparticles with superparamagnetic, photoacoustic, fluorescence, and photothermal properties, the nanoenzymes are able to increase the imaging sensitivity and accuracy for better understanding the complexity and the biological process of disease. Moreover, these functions encourage the utilization of nanozymes as therapeutic agents to assist in treatment. In this review, we focus on the applications of nanozymes in molecular imaging and discuss the use of peroxidase (POD), oxidase (OXD), catalase (CAT), and superoxide dismutase (SOD) with different imaging modalities. Further, the applications of nanozymes for cancer treatment, bacterial infection, and inflammation image-guided therapy are discussed. Overall, this review aims to provide a complete reference for research in the interdisciplinary fields of nanotechnology and molecular imaging to promote the advancement and clinical translation of novel biomimetic nanozymes.

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Section: Nanozymes For Molecular Imagingmentioning

confidence: 99%

Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges

et al. 2023

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“…Cy7’s appeal lies in its negligible fluorescent background and an enduring imaging period within the spectral range of 700–1000 nm [ 29 – 31 ]. Furthermore, Cy7’s unique to absorb near-infrared light and convert it into heat positions as a valuable asset for photothermal therapy [ 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Integration of photomagnetic bimodal imaging to monitor an autogenous exosome loaded platform: unveiling strong targeted retention effects for guiding the photothermal and magnetothermal therapy in a mouse prostate cancer model

Liu,

Shang,

Song

et al. 2024

J Nanobiotechnol

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Background Prostate cancer (PCa) is the most prevalent cancer among males, emphasizing the critical need for precise diagnosis and treatment to enhance patient prognosis. Recent studies have extensively utilized urine exosomes from patients with cancer for targeted delivery. This study aimed to employ highly sensitive magnetic particle imaging (MPI) and fluorescence molecular imaging (FMI) to monitor the targeted delivery of an exosome-loaded platform at the tumour site, offering insights into a potential combined photothermal and magnetic thermal therapy regime for PCa. Results MPI and FMI were utilized to monitor the in vivo retention performance of exosomes in a prostate tumour mouse model. The exosome-loaded platform exhibited robust homologous targeting ability during imaging (SPIONs@EXO-Dye:66·48%±3·85%; Dye-SPIONs: 34·57%±7·55%, **P<0·01), as verified by in vitro imaging and in vitro tissue Prussian blue staining. Conclusions The experimental data underscore the feasibility of using MPI for in vivo PCa imaging. Furthermore, the exosome-loaded platform may contribute to the precise diagnosis and treatment of PCa. Graphical Abstract

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“…In our previous studies, a series of nonionic heptamethine cyanines (Cy7‐TCFs) with tunable push‐pull electronic structure could form π ‐aggregates, which can quench the fluorescence and ISC through sufficient intra‐/intermolecular electron transfer process to enhance photothermal conversion efficiency. [ 6a,c,9 ] Notably, the stacking pattern of molecules in these supramolecular aggregates is governed not only by the shape of the assembling molecules, but also by the set of weak and short‐range interactions that hold them together. The intermolecular interactions, steering the aggregation of molecules and controlling their structure and function, are a complex interplay that is tremendously difficult to understand and predict.…”

Section: Introductionmentioning

confidence: 99%

Heptamethine Cyanine‐Based Nanotheranostics with Catalase‐Like Activity for Synergistic Phototherapy of Cancer

Liang

et al. 2023

Adv Funct Materials

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Single‐molecule photosensitizers (PSs) for synergistic phototherapy are desirable but highly challenging, due to the competitive relationship between photothermal (PTT) and photodynamic therapy (PDT). Herein, a supramolecular strategy is developed that can tune the stacking pattern of PS molecules in their aggregates to optimize the PTT/PDT efficiency. Specifically, near‐infrared (NIR) heptamethine cyanines (Cy7) are synthesized using tricyanofuran (TCF) as the acceptor and benzothiazole (BTH)/indole (IND) as the donor, where BTH is a less hydrogen‐bonded tecton relative to IND. Both IND‐Cy7‐TCF and BTH‐Cy7‐TCF have similar photophysical properties at the molecular level, but BTH‐Cy7‐TCF in aggregated state exhibits higher singlet oxygen quantum yield (1.3% vs 0.2%) and competitive photothermal conversion efficiency (56.4% vs 62.3%) compared to IND‐Cy7‐TCF, due to the fine‐tuning of hydrogen bonding and intermolecular π–π interactions to form loose molecular stacks. Interestingly, the unique molecular stacking structure provides a binding site and catalytic center for H2O2 that exhibits catalase‐like activity, which can further ameliorate the efficiency of PDT and enhance the synergistic effect of PDT/PTT phototherapy in vitro and in vivo. This study can provide a simple but effective supramolecular strategy to design small molecule PSs with desirable aggregated structure for synergistic dual‐mode phototherapy.

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A Simple Small Molecule with Synergistic Passive and Active Dual-Targeting Effects for Imaging-Guided Photothermal Cancer Therapy

Cited by 15 publications

References 42 publications

Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges

Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges

Integration of photomagnetic bimodal imaging to monitor an autogenous exosome loaded platform: unveiling strong targeted retention effects for guiding the photothermal and magnetothermal therapy in a mouse prostate cancer model

Heptamethine Cyanine‐Based Nanotheranostics with Catalase‐Like Activity for Synergistic Phototherapy of Cancer

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