A simple signal-on strategy for fluorescent detection of tuberculostatic drug isoniazid based on Ag clusters-MnO2 sheets nanoplatform

Zhao, Yannan; Zhang, Xinwen; Jia, Chunyan; Wu, Jiangling; Tang, Hua; Shang, Jinsai; Yuan, Chuanji; Wang, Yi; Zhang, Pu

doi:10.1016/j.colsurfb.2021.111627

Cited by 12 publications

(13 citation statements)

References 40 publications

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“…In addition, the high-resolution transmission electron microscopy (HRTEM) analysis of the Ag nanoclusters in the supernatant is shown in Figure 7 d; the Ag nanoclusters were spherical with a clear lattice fringe, indicating the formation of Ag nanoclusters. Due to their ultra-small sizes, Ag nanoclusters possess unique physical and chemical properties compared with those of larger-sized nanoparticles, and there have been reports about Ag nanoclusters being used as electrochemical catalysts [ 44 , 45 ], fluorescence-based sensors [ 46 , 47 ], preparation materials for optical fibers [ 48 ], etc. Therefore, the prepared Ag nanoclusters could have wide applications in many areas.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Xylan-Click-Quaternized Chitosan via Click Chemistry and Its Application in the Preparation of Nanometal Materials

et al. 2022

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For the high-valued utilization of hemicelluloses and for realizing the controllable synthesis of NPs, this paper’s aim is to combine xylan, chitosan and nanometal materials at the same time. In this research study, firstly, propargyl xylan was synthesized via nucleophilic substitution reaction between xylan and propargyl bromide in NaOH solution. On the other hand, a tosyl group was introduced onto the 6th position of synthesized quaternized chitosan (QCS), and the azide group replaced the tosyl group to obtain 6-amido-QCS (QCS-N3). The synthesis conditions of the above reactions were optimized. Subsequently, the novel xylan-click-QCS polymer was obtained via click reaction between terminal alkyne groups on the xylan chains and azide groups on QCS. Then, AgNPs and AuNPs were synthesized by adopting the xylan-click-QCS polymer as the reducing and stabilizing agent, and the reaction conditions were optimized to obtain well-dispersed and highly stable nanoparticles. There were two kinds of Ag nanomaterials, with diameters of 10~20 nm and 2~5 nm, respectively, indicating the formation of Ag nanoclusters, except for Ag nanoparticles, in this reaction. The diameter of the synthesized AuNPs was 20~30 nm, which possessed a more uniform size distribution. The Ag nanoclusters with a smaller size (2~5 nm) could inhibit MCF-7 cell proliferation effectively, indicating their application potential in cancer therapy. The study gives a new approach to the high-value utilization of biopolymers.

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Section: Resultsmentioning

confidence: 99%

Synthesis of Xylan-Click-Quaternized Chitosan via Click Chemistry and Its Application in the Preparation of Nanometal Materials

et al. 2022

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“…Fluorescent metal nanodots, such as UCNPs, gold nanoclusters (AuNCs) and silver nanoclusters (AgNCs), with their unique optical properties, large Stokes shift, enhanced penetration ability, and negligible autofluorescence are useful in sensing applications. Over a period, a good number of sensing systems based on fluorescent metal nanodots and MnO 2 NSs are used in sensing and imaging applications. − …”

Section: Sensing Applicationsmentioning

confidence: 99%

Review of 2D MnO₂ Nanosheets as FRET-Based Nanodot Fluorescence Quenchers in Chemosensing Applications

Hiremath

Banerjee

Chatterjee

2022

ACS Appl. Nano Mater.

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In the past decade, a variety of MnO 2 nanostructures have been used in chemosensing applications because of their unique redox properties, structural diversity, and broad absorption band, which makes them good energy acceptors. The most common strategy in Forster (or fluorescence) resonance energy transfer (FRET)-based chemosensing assays is to use low-dimensional fluorescent dots like carbon-based dots, metal dots, and even fluorescent dyes to form donor−acceptor pairs with 2D MnO 2 nanosheets (NSs). This review is a collection of the current library on fluorescent nanodots and MnO 2 NSs-based FRET conjugates as sensing platforms with a focus on highlighting the strategies involved in the detection of various analytes. Commonly, an analyte-triggered redox reaction results in the decomposition of MnO 2 NSs, leading to the release of fluorescent nanodots in solution for the turn-on detection of various reducing species. We intend to elaborately discuss the systematic upgradation of detection strategies involving fluorescent dots@2D MnO 2 NSs. Recently, a cascade of redox reactions was judiciously employed to target several bioanalytes involving a fluorescent dots@MnO 2 NSs FRET conjugate in a selective and sensitive manner. These sensing assays are categorized by the use of different fluorescent nanodots [carbon dots (CDs) and graphene quantum dots (GQDs), polymer dots, metal dots, etc.] with 2D MnO 2 NSs as FRET pairs in different sensing applications. Further, the analytes were categorized as reducing species, oxidants, enzymes, microbes, etc. The focus was paid to the sensing efficiency of the analytical tool. As a part of the study, a brief account of the synthesis of nanodots and MnO 2 NSs, their properties, and the FRET mechanism is also included. In a few cases, the sensing mechanism follows an inner filter effect without a prerequisite of the distance between the fluorophore and quencher units in the sensing of analytes, which are also covered in this collection. The available literature indicates a bright future for these FRET-based contemporary sensing strategies as environmentally benign, cost-effective, label-free techniques, which are discussed in the end.

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“…Tuberculosis has been a major threat to human health worldwide for decades. To clinically treat tuberculosis, isoniazid is one of the most efficient first-line and widely used anti-tuberculosis drugs because of its excellent therapeutic effect, good tolerability, and low toxicity. , However, the effectiveness of clinical trials in treating patients is closely related to the dose of isoniazid. The optimal dose for an adult is very narrowly defined, which is usually 4–6 mg/kg, and is usually necessary to be used in conjunction with other drugs to treat tuberculosis over a six-month treatment period. , Therefore, irrational administration not only raises the possibility of drug resistance but also leads to adverse therapeutic effects and side effects.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the quantitative detection of isoniazid in biological samples and drugs is essential for both disease treatment and public surveillance. At present, there are plenty of detection ways for isoniazid, including high-performance liquid chromatography (HPLC), atomic absorption spectrometry, fluorescence spectrometry, electrochemical detection, etc. ,− Although these assays have their own advantages, they usually require time-consuming and laborious sample pre-treatment. In addition, portability is also a problem.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of a Tubular CuO/NiO Biomimetic Nanozyme with Synergistically Promoted Peroxidase-like Performance for Isoniazid Sensing

et al. 2022

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Isoniazid is an antibiotic primarily used in clinical treatment of tuberculosis, but excessive usage can lead to serious consequences such as hepatotoxicity, neurotoxicity, and even coma and death. Therefore, it is critical to exploit a quick, facile, and acute way for isoniazid analysis. In this work, we have demonstrated an efficient electrospinning–carbonation–wet chemistry reaction–calcination process to fabricate CuO/NiO nanotubes (NTs) as a promising nanozyme for peroxidase (POD) mimicking. In virtue of the distinct tubular structure and synergy between CuO and NiO from the mechanisms of both electron transfer and hydroxyl radical generation, a remarkably improved catalytic activity is realized for the CuO/NiO NTs compared with bare CuO and NiO samples. According to the admirable POD-like property, a rapid colorimetric detection for isoniazid is accomplished with a detection limit of 0.4 μM (S/N = 3) and favorable selectivity. In addition, the sensing capability of isoniazid in a real sample is also investigated with satisfactory results. This work offers a novel tactic to fabricate high-performance nanozymes with efficient isoniazid sensing capabilities to address challenges in disease treatment efficacy and public safety monitoring.

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A simple signal-on strategy for fluorescent detection of tuberculostatic drug isoniazid based on Ag clusters-MnO2 sheets nanoplatform

Cited by 12 publications

References 40 publications

Synthesis of Xylan-Click-Quaternized Chitosan via Click Chemistry and Its Application in the Preparation of Nanometal Materials

Synthesis of Xylan-Click-Quaternized Chitosan via Click Chemistry and Its Application in the Preparation of Nanometal Materials

Review of 2D MnO₂ Nanosheets as FRET-Based Nanodot Fluorescence Quenchers in Chemosensing Applications

Fabrication of a Tubular CuO/NiO Biomimetic Nanozyme with Synergistically Promoted Peroxidase-like Performance for Isoniazid Sensing

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A simple signal-on strategy for fluorescent detection of tuberculostatic drug isoniazid based on Ag clusters-MnO2 sheets nanoplatform

Cited by 12 publications

References 40 publications

Synthesis of Xylan-Click-Quaternized Chitosan via Click Chemistry and Its Application in the Preparation of Nanometal Materials

Synthesis of Xylan-Click-Quaternized Chitosan via Click Chemistry and Its Application in the Preparation of Nanometal Materials

Review of 2D MnO2 Nanosheets as FRET-Based Nanodot Fluorescence Quenchers in Chemosensing Applications

Fabrication of a Tubular CuO/NiO Biomimetic Nanozyme with Synergistically Promoted Peroxidase-like Performance for Isoniazid Sensing

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Review of 2D MnO₂ Nanosheets as FRET-Based Nanodot Fluorescence Quenchers in Chemosensing Applications