A simple <scp>HPLC</scp> method for the simultaneous determination of two selective serotonin reuptake inhibitors and two serotonin–norepinephrine reuptake inhibitors in hair, nail clippings, and cerebrospinal fluid

Samanidou, Victoria F.; Pantazidou, Kristallenia; Kovatsi, Leda; Njau, Samuel; Livanos, Aristidis

doi:10.1002/jssc.201100849

Cited by 18 publications

(10 citation statements)

References 20 publications

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“…Samanidou et al 34 presented a HPCL‐DAD method for the detection of venlafaxine, duloxetine, fluoxetine, and paroxetine in hair, nail clippings, and cerebrospinal fluid. After validation, the method was applied to the hair and nail samples of a patient undergoing fluoxetine therapy.…”

Section: Methods Development and Validation Publicationsmentioning

confidence: 99%

Hair analysis of antidepressants and antipsychotics—Overview of quantitative data

Methling

Krumbiegel

Härtwig

2020

Drug Testing and Analysis

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Antidepressant and antipsychotic drugs are regularly encountered in different aspects of forensic toxicology, and some cases require the examination of hair samples. In this study, common antidepressant and antipsychotic drugs regarding hair concentrations over the past decades were reviewed. Although numerous publications around method validations, case reports, or controlled dose studies were found, apparently there is a lack of comprehensive data for many substances. Information on the hair length and dosage across the publications varied largely, and case numbers were generally low except for several retrospective controlled dose studies. Many substances were described only in method validations or case reports, and data were obtained from small case numbers. On the contrary, clozapine, haloperidol, amitriptyline, nortriptyline, risperidone and its metabolite, methylphenidate, citalopram, chlorpromazine, chlorprothixene, and quetiapine had a well‐founded database as these substances were investigated in controlled dose studies with higher case numbers. Given the advancements made in analytical techniques over the past years, gas chromatography–mass spectrometry and liquid chromatography with tandem mass spectrometry techniques were the methods of choice and allowed the detection of chemical compounds at low concentrations. The controversy around a potential use of hair analysis to estimate the dosage remains as dose‐concentration studies provided divergent results. A harmonization on the investigated hair length as well as on the extraction protocol would be of favor to achieve better comparability. Although hair analysis research focused mainly on drug abuse, availability of more data on antidepressants and antipsychotics would help to gain better knowledge and assist other forensic investigators.

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Section: Methods Development and Validation Publicationsmentioning

confidence: 99%

Hair analysis of antidepressants and antipsychotics—Overview of quantitative data

Methling

Krumbiegel

Härtwig

2020

Drug Testing and Analysis

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“…As comparison, the sensitivities of FTIR methods calculated as approximately are 100-200 times lower than HPLC. However, it is almost equal compared to spectrophotometry uv-visible [9,30,31]. Fortunately, this method in the next development, still can be improved by the standard addition method.…”

Section: Determination Of Papaverine Hcl Levels In Hair Samples Usingmentioning

confidence: 99%

The Rapid and Green Hair Analysis Method Development Using Ftir for Papaverine HCL Determination

2019

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Objective: This study was aimed to develop a rapid analysis using FTIR (Fourier Transform Infra-Red) for papaverine hydrochloride (HCl) determination in the hair sample, supported by a mathematically manipulation; which never been reported before in toxicology and forensic analysis.Methods: Firstly, the method was checked its validity to ensure the feasibility for the quantitative purpose. The absorbance spectrums were collected by measure the drug, matrix, and its mixture. A spectra which showed the best specificity and linearity then was selected and derived. Afterwards, the area under the curve (AUC) was measured. A series of concentration was used for compose the calibration curve. Based on the result, some validation parameters were checked thoroughly. Further, for sample preparation, hair was collected non-invasively, then was decontaminated using soap. Next, it was immersed into a papaverine HCl solution at a concentration of 25 mg/ml along days. Finally, the amount of drugs absorbed were measured by the developed method using FTIR. Results:Experimental data showed that all validation parameters could be fulfilled by the developed method. The selected spectra for the content determination was 1320-1230 cm -1 Conclusion: As the conclusion, FTIR absorbance-derivative method is adequate as a rapid procedure for determine papaverine HCl in the hair sample. This method shows the appropriate of specificity, accuracy and precise. In addition, it shows the advantages of simplicity, green/ecofriendlier, and cost-efficiency.. Its linearity was represented by a correlation coefficient value (r) ≥ 0.9999, variation coefficient (Vxo) ≤ 2.0%. The limit of detection (LOD) was 0.00618% w/w, meanwhile, the limit of quantitation (LOQ) was 0.02060% w/w, respectively. The percent recovery was in the range 97-103% with the relative standard deviation (RSD) was ≤ 2.0%. The drug has detected after 72 h immersion, moreover, after 192 h the concentration gained was 0.1594±0.0011% w/w. I In nt te er rn na at ti io on na al l J Jo ou ur rn na al l o of f A Ap pp pl li ie ed d P Ph ha ar rm ma ac ce eu ut ti ic cs s

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“…Some papers were reported for simultaneous determination of drugs used in treatment of ED [16][17][18] and some others were reported for simultaneous determination of some antidepressant drugs that can be abused in treatment of PE. 19,20 However, as discussed before, the co-administration of drugs for treatment of ED and PE is possible. Few methods were reported for co-determination of two drugs used for ED and PE such as SDN/DPX, 21,22 AVN/ DPX, 23,24 SDN/TMD 25 and SDN/YHB.…”

Section: Introductionmentioning

confidence: 99%

Core–shell particles and monolithic columns; tools for simultaneous LC analysis of avanafil, sildenafil, apomorphine, trazodone, yohimbine, tramadol and dapoxetine in pharmaceutical dosage forms, counterfeit products and human plasma

et al. 2020

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A simple HPLC method for the simultaneous determination of two selective serotonin reuptake inhibitors and two serotonin–norepinephrine reuptake inhibitors in hair, nail clippings, and cerebrospinal fluid

Cited by 18 publications

References 20 publications

Hair analysis of antidepressants and antipsychotics—Overview of quantitative data

Hair analysis of antidepressants and antipsychotics—Overview of quantitative data

The Rapid and Green Hair Analysis Method Development Using Ftir for Papaverine HCL Determination

Core–shell particles and monolithic columns; tools for simultaneous LC analysis of avanafil, sildenafil, apomorphine, trazodone, yohimbine, tramadol and dapoxetine in pharmaceutical dosage forms, counterfeit products and human plasma

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