A simple salicylaldehyde-based fluorescent “turn-on” probe for selective detection of Zn²⁺in water solution and its application in live cell imaging

Abstract

A water-soluble fluorescent probe for Zn2+based on a Schiff base derivative was prepared. It displays a rapid response toward Zn2+with selectivity and sensitivity and has been successfully applied to imaging in living cells.

A bifunctional sensor based on diarylethene for the colorimetric recognition of Cu2+ and fluorescence detection of Cd2+

“…Compared to the abovementioned methods, chemosensing as one of the most promising approaches has attracted more attention due to its advantages of a fast response, high sensitivity, high selectivity, and real-time analysis. 29,30 Up to now, great efforts have been devoted to develop highly selective and sensitive chemosensors for the detection of heavy metal ions. Although sensors for the colorimetric recognition of Cu 2+ (ref.…”

A hexa-quinoline basedC3-symmetric chemosensor for dual sensing of zinc(ii) and PPi in an aqueous mediumviachelation induced “OFF–ON–OFF” emission

“…Zinc is the second most abundant transition metal occurring in the human body and plays diverse roles in several vital biological processes like cellular metabolism, neurotransmission, etc. [1][2][3][4][5][6][7][8][9][10][11] In everyday life, zinc is found in various foods, automobiles, sunscreens, cosmetics and surgical tools etc. It exists mostly as Zn 2+ in the body as well as in nature.…”

“…12 However, misregulation of Zn 2+ causes several diseases like Alzheimer's, epilepsy, infantile diarrhea, prostate cancer, etc. [1][2][3][4][5][6][7][8][9][10][11][13][14][15][16][17] On the other hand, pyrophosphate (PPi), which is produced during ATP hydrolysis, is a crucial anion for normal cell functioning, e.g., it is involved in DNA polymerase catalyzed DNA replication and real time DNA sequencing. [18][19][20][21][22][23][24][25][26][27][28][29] So, it is highly desirable to explore efficient methods to detect and monitor Zn 2+ and PPi in environmental as well as in biological samples.…”

“…and their derivatives, involving photoinduced electron transfer (PET), intermolecular charge transfer (ICT) and chelation induced enhanced fluorescence (CHEF) mechanisms, [1][2][3]8,12,21,48 the number of sensors capable of selectively sensing Zn 2+ in an aqueous buffer through a wide range of pH values is still limited. [4][5][6]41,[49][50][51] In this context, among different types of fluorescent zinc sensors, quinoline substituted ligands have been paid much attention due to their well-known chelating property towards soft metals as well as suitable spectral behavior. 1,41,[42][43][44][45][46] It has also been observed that, in some cases, an increase in the number of quinoline units in the binding arm improves the sensitivity.…”

Detection of Zinc(II) by a Fluorescence Chemosensor Based on Benzofuran in Aqueous Media and Live Cells

“…Among the moieties, Schiff bases can be synthesized simply and perform as binding site . In addition, benzofuran and salicylaldehyde moieties could serve as fluorophore and binding sites . Considering these characters, we combined 3‐aminobenzofuran‐2‐carboxamide and salicylaldehyde to develop a new Schiff base fluorescence chemosensor.…”