A simple route to cyclopentane annulation

“…Due to interesting biological properties of quinoxaline system, in 1997, we have demonstrated the synthesis of quinoxaline‐containing AAA derivatives (Scheme ) . Later, this strategy has been extended with solid support.…”

Section: α‐Amino Acidsmentioning

confidence: 99%

Development of New Synthetic Strategies, Tactics and their Applications

Kotha

Meshram

2019

The Chemical Record

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This account covers our work related to the development of various synthetic methodologies since 1994. We summarized our strategies and their application to design various functional molecules. In this regard, we also report the utility of our methodologies in others research work. These methods we report here are simple and efficient for the synthesis of a wide variety of intricate molecules such as heterocycles, polycycles, unusual α‐amino acids, star‐shaped molecules, and modified peptides. For this purpose, we used various transition metal‐based reagents and catalysts. Various popular reactions such as metathesis, Suzuki coupling, [2+2+2] cyclotrimerization were used to assemble these targets. Moreover, rongalite has been used to expand the Diels‐Alder chemistry.

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“…Successively, catalytic hydrogenation of the major tetracyclic dione in ethyl acetate containing 10 % Pd/C resulted in the saturated tetracyclic dione 246a . A similar strategy was implemented for the synthesis of hexacyclic dione 248b from tetracyclic dione 246a (Scheme ).…”

Section: Miscellaneous Strategiesmentioning

confidence: 99%

Design and Synthesis of Spirocycles

2017

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In this account we disclose a variety of simple strategies demonstrated in our laboratory in the last two decades for the assembly of diverse and intricate molecular frameworks containing spiro linkage(s) by using various metathesis protocols such as ring‐closing metathesis (RCM), ring‐opening cross‐metathesis (ROCM), ring‐closing enyne metathesis (RCEM) and ring‐rearrangement metathesis (RRM). Also, cycloaddition reactions ([2+2], [4+2] and [2+2+2]) and other key processes such as Claisen rearrangement (CR), Grignard addition, Fischer indolization (FI), Suzuki–Miyaura (SM) cross‐coupling and the retro‐Diels–Alder (rDA) reaction have been used as key steps to construct spirocycles.

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A simple route to cyclopentane annulation

Cited by 13 publications

References 14 publications

Synthetic Approaches to Natural and Unnatural Tetraquinanes

Synthetic Approaches to Natural and Unnatural Tetraquinanes

Development of New Synthetic Strategies, Tactics and their Applications

Design and Synthesis of Spirocycles

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