“…Thus, typical scaffolds include cyclodextrins, cyclophanes, calixarene mimics and other macrocyclic compounds 2, 6–10, 22, 24, 25. Apart from synthesized macrocyclic compounds, macromolecule‐based scaffolds, such as synthesized dendrimer, hydrogels21 and polymers,22, 23 as well as biomacromolecules11, 12 with specific recognition for substrates,11–18 and more importantly, for transition states have been developed 15. Recently, the design concept of nanozyme may open up a new way to design more complicated enzyme models 19, 20.…”