A Simple Over-Oxidized Molecularly Imprinted Polypyrrole for the Sensitive Detection of Dopamine in Human Serum

Abstract

A simple electrochemical sensor for dopamine detection, is based on molecularly imprinted and electropolymerized over-oxidized polypyrrole (OPPy). The MIP-based electrode is obtained by electrocopolymerization of pyrrole (0.1 M) in the presence of the template molecular (dopamine, DA) (10 −3 M). The square wave voltammetry (SWV) is used for the detection of dopamine in buffer solution. The current peak obtained at the MIP electrode was proportional to the logarithm of the DA concentration in the range of 10 −11 to 5 × 10 −8 M with a detection limit of 10 −11 M. The proposed sensor was used for the detection of DA in spiked blood serum, satisfactory results were obtained.