A Simple Optical Reader for Upconverting Phosphor Particles Captured on Lateral Flow Strip

Huang, Lihua; Zhou, Lei; Zhang, Youbao; Xie, Chengke; Qu, Jianfeng; Zeng, Aijun; Huang, Huijie; Yang, Ruifu; Wang, Xiangzhao

doi:10.1109/jsen.2009.2027416

Cited by 26 publications

(22 citation statements)

References 20 publications

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“…Optical detection is ensured by a small portable device incorporating a 980-nm diode laser and a small photomultiplier for measuring the emitted visible light, linked to a data acquisition and calculator module. A micro-stepping motor provides the movement for scanning the plate (scanning range 10 mm, resolution 0.02 mm) [73]. Novel developments include coupling UCNP-based assays with complementary metal-oxide-semiconductor CMSO technology for signal detection and processing.…”

Section: Point Of Care Analysis: Lateral Flow Analysis and Microarraysmentioning

confidence: 99%

Lanthanide light for biology and medical diagnosis

Bünzli

2016

Journal of Luminescence

268

134

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Section: Point Of Care Analysis: Lateral Flow Analysis and Microarraysmentioning

confidence: 99%

Lanthanide light for biology and medical diagnosis

Bünzli

2016

Journal of Luminescence

268

134

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“…The UCPs may be mounted on the LF strip in advance to allow a very simple assay procedure involving only addition of the sample (single flow format) [150,151]. An alternative version is called the consecutive flow format, which involves a washing step to remove unbound sample material before addition of the UCP conjugate to the LF strip [152,153].…”

Section: Lateral Flow Testsmentioning

confidence: 99%

Upconverting Phosphor Labels for Bioanalytical Assays

Riuttamäki

Soukka

2013

Advances in Chemical Bioanalysis

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Upconverting phosphors (UCPs) are photoluminescent inorganic crystals capable of photon upconversion upon absorption of two or more sequential photons. UCPs produce bright, structured emission at wavelengths shorter than the excitation radiation rendering them highly advanced labels for bioanalytical assays. The exceptional anti-Stokes emission allows total elimination of autofluorescence originating mainly from biomolecules and other sample components. UCPs are excited with near-infrared radiation which provides several advantages over ultraviolet excitation-including optimal penetration of biological material. This chapter summarizes the bioanalytical in vitro applications of UCPs and discusses the advantages and challenges of the emerging label technology. In addition, synthesis of the UCP labels and some of the instruments used for UCP detection are shortly reviewed. Bioimaging and therapeutic applications based on UCPs are outside of the scope of this chapter.

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“…UCNs have been used as luminescent reporters in a variety of assays, including immune-assay, bioaffinity assay, and DNA hybridization assay as alternatives to conventional labeling agents (Zijlmans, 1999;Hampl, 2001;Corstjens, 2008;Huang, 2009). A example was demonstrated by submicron-sized Y 2 O 2 S particles doped with Yb 3+ and Er 3+ ions for detection of human chorionic gonadotropin with a limit of 10 pg in a lateral flow (LF) immune-chromatographic assay format (Hampl, 2001).…”

Section: Application Of Up-converting Nanoparticles For Biological Sementioning

confidence: 99%