A Simple One‐pot Synthesis of Indeno[2,1‐f]quinolin‐3‐one Derivatives under Microwave Irradiation

Abstract

A series of new indeno[2,1-f]quinolin-3(2H)-one derivatives were synthesized by a reaction of aromatic aldehyde with Meldrum's acid (2,2-dimethyl-1,3-dioxane-4,6-dione) and 9H-fluoren-2-amine under microwave irradiation without catalyst in glacial acetic acid. This reaction has notable advantages of short reaction time, high yield and convenient operation.

Active Methylene-based Multicomponent Reactions under Microwave Heating

“…[35] A similar method to produce indeno[2,1-f]quinolin-3(2H)-one derivatives has been described by the same group. [36] In 2010, Tu and Li reported multicomponent domino reactions (MDRs) for the synthesis of spiro{pyrazolo [1,3]-dioxanopyridine}-4,6-diones 17, and spiro{isoxazolo [1,3] dioxanopyridine}-4,6-diones 17 (Scheme 14). The MDRs were conducted by reacting Meldrum's acid, aromatic aldehydes and 3-methyl-1-phenylpyrazol-5-amine in aqueous solution under microwave irradiation.…”