“…Various approaches are practiced for SPG block like trans-nasal, trans-oral, sub-zygomatic, and lateral infratemporal approaches. The trans-nasal SPG block is a simple, noninvasive technique, 47 which can be achieved by local anesthetic administration through a hollow cotton tip applicator, trans-nasal local anesthetic spray or puffs, 48 trans-nasally inserted cotton gauze soaked in local anesthetic 49 and nasal drops of local anaesthetic, 50 although, the last three methods cannot ensure adequate concentration of local anesthetic reaching the effective site to be blocked. In this meta-analysis, one study compared SPG block with local anesthetic spray (lignocaine puffs) and subgroup analysis of the same observed superiority of SPG block over lignocaine puff for pain relief at 30 min, 1 h, 6 h, 12 h, and 24 h. However, this data was from only one study with a small sample size of 20 patients, therefore more studies with large sample sizes are needed for evaluating potential advantage of using local anesthetic spray or puff over trans nasal block with cotton tip applicator.…”