A Simple Method for the Quantitation of Submicrogram Amounts of Bacterial Endotoxin,

A New Method for Biological Assay of Endotoxin Using Change in Peripheral Leukocyte Population in Mice as a Response

“…Recently, attempts at increasing susceptibility of experimental animals to endotoxin have been reported (Moon and Berry, 1968;Moon, 1972;Pieroni et al, 1970;.Filkins, 1970;Dowling and Feldman, 1970;Levin, Tomasulo and Osler, 1970;Wong ASSAY OF ENDOTOXIN USING LEUKOCYTE CHANGE et al, 1973). Studies on this subject are in progress (Kuratsuka et al, 1972 * The standard error , 0.155, given by Spaun et al (1945) was used for the calculation of the fiducial limits.…”

Enhanced Toxicity for Mice of Vincristine and Other Chemotherapeutic Agents with Salmonella typhosa Endotoxin and Pseudomonas aeruginosa

“…Residual endotoxin in the incubation mixtures was assayed by a modification of the methods of Pieroni et al (10) and Dowling and Feldman (4). The incubated samples were administered to mice previously stressed with 0.8 mg of actinomycin D per kg.…”

Symposium on Toxins

“…( , 1970c, Hirata et al (1970aHirata et al ( , 1971aHirata et al ( , 1971b) and also by Abe et al (1970 and that of RBC on the first or the second day after endotoxin injection in the absolute count method . Pieroni et al (1970) reported that predose of Actinomycin D enhanced the lethality of endotoxin in mice over 100,000-fold. As a positive bone marrow reaction was already observed 18 hr after Actinomycin D injection, it was not easy to observe the influence of injection of a mixture of Actinomycin D and endotoxin.…”