A Simple Method for the Determination of the Thread-Forming Property of Tracheobronchial Secretions

Abstract

A method is described for determining the thread-forming property (‘Spinn-barkeit’) of tracheobronchial secretions. With this method it was observed that adrenergic compounds increase the length of the mucus threads by an average of 154% whereas mucolytic agents caused an average decrease of 63 % in the length of the mucus threads.

Clinical Efficacy of Ambroxol in the Treatment of Bronchial Stasis. Clinical Trial in 120 Patients at Two Different Doses

“…Several hu man studies showed that ambroxol affects the secretomotor activity of serous glands [13,14], facilitates the repair of bronchial epithelium [15], and accelerates mucocil iary transport (in vitro model using frog palate) [16] and clearance [99mTc-labeIed secretions; ref. 17], However, as no effect was demonstrated on the viscoelasticity of bronchial secretion, ambroxol is not a true mucolytic agent [18). The aim of this trial was to determine, as previous ly investigated, the clinical efficacy of ambroxol in the treatment of bronchial stasis and also includes the following studies: study A using a daily dose of 120 mg which was considered an effective dose and study B, using a daily dose of 30 mg to determine an effective minimum dose.…”

Pharmacodynamic Mechanism and Therapeutic Activity of Ambroxol in Animal Experiments

“…It is not conclusive to explain increased transport rates of up to 300%, compared to the control rates, by a 10% stimulation Guinea pig tracheal ciliated cells 1-100 qmol/l increase in beat frequency up to 11 % this study in vitro of the ciliary activity; therefore, we need a better explanation: Iravani and Melville [2] showed that the spinability of rat air way mucus, a measure of consistency, was decreased by 62% after incubation of the excised airways in 12 /xmol/l of ambroxol. Usually, there is a correlation between changes in spinability and in the elasticity of mucus.…”