A simple method for fabricating microwire tetrode with sufficient rigidity and integrity without a heat-fusing process

Liao, Yi-Fang; Tsai, Meng‐Li; Yen, Chen‐Tung; Cheng, Chiung-Hsiang

doi:10.1016/j.jneumeth.2010.12.017

Cited by 12 publications

(4 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The electrode microdrive arrays consisted of three or four 00–90 screws each attached to a 31 gauge stainless steel (SS) tube carrying a polytrode. Polytrodes were fabricated [per suggestions by (Liao et al, 2011 ); by winding (using a solution stirrer) 12 um diameter NiCr wires (Sandvik Fine Wire) into a spiraled bundle] and placed inside of a 25 ga SS tube aimed at the striatum. The entire assembly was housed inside of cylindrical plastic tubing sitting atop a polycarbonate plastic base.…”

Section: Methodsmentioning

confidence: 99%

Hyperactive Response of Direct Pathway Striatal Projection Neurons to L-dopa and D1 Agonism in Freely Moving Parkinsonian Mice

Sagot

Zhou

2018

Front. Neural Circuits

View full text Add to dashboard Cite

Dopamine (DA) profoundly stimulates motor function as demonstrated by the hypokinetic motor symptoms in Parkinson's disease (PD) and by the hyperkinetic motor side effects during dopaminergic treatment of PD. Dopamine (DA) receptor-bypassing, optogenetics- and chemogenetics-induced spike firing of striatal DA D1 receptor (D1R)-expressing, direct pathway medium spiny neurons (dSPNs or dMSNs) promotes movements. However, the endogenous D1R-mediated effects, let alone those of DA replacement, on dSPN spike activity in freely-moving animals is not established. Here we show that using transcription factor Pitx3 null mutant (Pitx3Null) mice as a model for severe and consistent DA denervation in the dorsal striatum in Parkinson's disease, antidromically identified striatonigral neurons (D1R-expressing dSPNs) had a lower baseline spike firing rate than that in DA-intact normal mice, and these neurons increased their spike firing more strongly in Pitx3Null mice than in WT mice in response to injection of L-dopa or the D1R agonist, SKF81297; the increase in spike firing temporally coincided with the motor-stimulating effects of L-dopa and SKF81297. Taken together, these results provide the first evidence from freely moving animals that in parkinsonian striatum, identified behavior-promoting dSPNs become hyperactive upon the administration of L-dopa or a D1 agonist, likely contributing to the profound dopaminergic motor stimulation in parkinsonian animals and PD patients.

show abstract

Section: Methodsmentioning

confidence: 99%

Hyperactive Response of Direct Pathway Striatal Projection Neurons to L-dopa and D1 Agonism in Freely Moving Parkinsonian Mice

Sagot

Zhou

2018

Front. Neural Circuits

View full text Add to dashboard Cite

show abstract

“…Based on a previous work [8], local field potentials (LFPs) were recorded from the VC using custom tetrodes fabricated by twisting four 25-m diameter insulated nichromium wires (Advent, Oxford, England) as described by Liao and coworkers [9]. The tips of the electrodes were then gold plated to reduce their impedance to below 500 k.…”

Section: B Electrophysiological Recordingsmentioning

confidence: 99%

Cross-modal activation of the primary visual cortex by auditory stimulation in RCS rats: considerations in visual prosthesis

Caravaca-Rodriguez

Suaning

Barriga‐Rivera

2022

2022 44th Annual International Conference of the IEEE Engineering in Medicine &Amp; Biology Society (EMBC)

View full text Add to dashboard Cite

“…The viability of microwire electrodes for neuronal recordings in live mammals was first demonstrated in 1958 by Strumwasser [ 4 ] using 80 μ m diameter stainless steel wire electrodes. Since then, a wide variety of materials, including stainless steel (SS) [ 5 ], tungsten (W) [ 6 ]–[ 11 ], Ni-Cr [ 12 ], Pt-Ir [ 13 ], [ 14 ], carbon fiber [ 15 ], [ 16 ], and conducting polymer [ 17 ], have been used. At the same time, development of micro-electro-mechanical systems (MEMS) enabled the use of silicon probes for very high channel count recordings from densely-spaced leads [ 18 ]–[ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Flexible High-Resolution Force and Dimpling Measurement System for Pia and Dura Penetration During In Vivo Microelectrode Insertion Into Rat Brain

Chen

Hartner²,

Dong³

et al. 2021

IEEE Trans. Biomed. Eng.

View full text Add to dashboard Cite

Objective: Understanding the in vivo force and tissue dimpling during micro-electrode implantation into the brain are important for neuro-electrophysiology to minimize damage while enabling accurate placement and stable chronic extracellular electrophysiological recordings. Prior studies were unable to measure the sub-mN forces exerted during in vivo insertion of small electrodes. Here, we have investigated the in vivo force and dimpling depth profiles during brain surface membrane rupture (including dura) in anesthetized rats. Methods: A µ N-resolution cantilever beam-based measurement system was designed, built, and calibrated and adapted for in vivo use. A total of 244 in vivo insertion tests were conducted on 8 anesthetized rats with 121 through pia mater and 123 through dura and pia combined. Results: Both microwire tip sharpening and diameter reduction reduced membrane rupture force (insertion force) and eased brain surface penetration. But dimpling depth and rupture force are not always strongly correlated. Multi-shank silicon probes showed smaller dimpling and rupture force per shank than single shank devices. Conclusion: A force measurement system with flexible range and µ N-level resolution (up to 0.032 µ N) was achieved and proved feasible. For both pia-only and dura-pia penetrations in anesthetized rats, the rupture force and membrane dimpling depth at rupture are linearly related to the microwire diameter. Significance: We have developed a new system with both µ N-level resolution and capacity to be used in vivo for measurement of force profiles of various neural interfaces into the brain. This allows quantification of brain tissue cutting and provides design guidelines for optimal neural interfaces.

show abstract

A simple method for fabricating microwire tetrode with sufficient rigidity and integrity without a heat-fusing process

Cited by 12 publications

References 16 publications

Hyperactive Response of Direct Pathway Striatal Projection Neurons to L-dopa and D1 Agonism in Freely Moving Parkinsonian Mice

Hyperactive Response of Direct Pathway Striatal Projection Neurons to L-dopa and D1 Agonism in Freely Moving Parkinsonian Mice

Cross-modal activation of the primary visual cortex by auditory stimulation in RCS rats: considerations in visual prosthesis

Flexible High-Resolution Force and Dimpling Measurement System for Pia and Dura Penetration During In Vivo Microelectrode Insertion Into Rat Brain

Contact Info

Product

Resources

About