A simple method for developing lysine targeted covalent protein reagents
Ronen Gabizon,
Barr Tivon,
Rambabu N. Reddi
et al.
Abstract:There is a growing demand for covalent tool compounds and chemical probes to investigate and perturb protein function and dysregulation. The combination of a covalent electrophile with a peptide or protein-based scaffold with an extended binding footprint enables the targeting of shallow protein surfaces, not typically addressable using small molecules. However, to fully exploit the potential of electrophilic proteins or peptides there is a need for versatile approaches to convert native peptide sequences into… Show more
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