A Simple Laboratory Potentiostat

Bentley, Molly; Denham, A. G.

doi:10.1179/000705970798324432

Cited by 3 publications

(1 citation statement)

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“…Such aptamer-based biosensors require pulse voltammetry techniques like square wave voltammetry (SWV) [13] to obtain the necessary sensitivity to accurately quantify the signal produced by the aptamer upon binding to the analyte. 2 of 12 Due to the growing popularity of electrochemical biosensors, numerous in-house potentiostats have been presented in the literature [9,[14][15][16][17][18][19][20][21][22][23][24][25][26][27]. Such designs aim to decrease the cost and increase the accessibility of potentiostats with the goal of democratizing scientific research or to miniaturize electrochemistry hardware for use in at-home or portable diagnostic devices.…”

Section: Introductionmentioning

confidence: 99%

KickStat: A Coin-Sized Potentiostat for High-Resolution Electrochemical Analysis

Hoilett

Walker

Balash

et al. 2020

Sensors

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The demand for wearable and point-of-care devices has led to an increase in electrochemical sensor development to measure an ever-increasing array of biological molecules. In order to move from the benchtop to truly portable devices, the development of new biosensors requires miniaturized instrumentation capable of making highly sensitive amperometric measurements. To meet this demand, we have developed KickStat, a miniaturized potentiostat that combines the small size of the integrated Texas Instruments LMP91000 potentiostat chip (Texas Instruments, Dallas, TX, USA) with the processing power of the ARM Cortex-M0+ SAMD21 microcontroller (Microchip Technology, Chandler, AZ, USA) on a custom-designed 21.6 mm by 20.3 mm circuit board. By incorporating onboard signal processing via the SAMD21, we achieve 1 mV voltage increment resolution and an instrumental limit of detection of 4.5 nA in a coin-sized form factor. This elegant engineering solution allows for high-resolution electrochemical analysis without requiring extensive circuitry. We measured the faradaic current of an anti-cocaine aptamer using cyclic voltammetry and square wave voltammetry and demonstrated that KickStat's response was within 0.6% of a high-end benchtop potentiostat. To further support others in electrochemical biosensors development, we have made KickStat's design and firmware available in an online GitHub repository.

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