A Simple Isocratic High-Performance Liquid Chromatographic (HPLC) Determination of Naproxen in Human Plasma using a Microbore Column Technique

Analytical Procedure for Determination of Cyclooxygenase-2 Inhibitors in Biological Fluids by High Performance Liquid Chromatography: A Review

“…Several high-performance liquid chromatographic methods have been published for the individual determination of nabumetone in biological fluids, serum and urine samples [17][18][19][20][21][22][23], however there have been no reports concerning the simultaneous determination of nabumetone and 6-MNA by isocratic HPLC. Direct injection of diluted urine [17,19,20] and liquid-liquid extraction as a sample clean-up procedure [14,17,19,22] are frequently used for the naphthalene derivatives in biological fluids.…”

“…Direct injection of diluted urine [17,19,20] and liquid-liquid extraction as a sample clean-up procedure [14,17,19,22] are frequently used for the naphthalene derivatives in biological fluids. For the liquid-liquid extrac-tion procedure, back extraction and/or some derivatization techniques induced to increase the sensitivity are often carried out to avoid interference substances [23][24][25].…”

Challenges in the simultaneous quantitation of sumatriptan and naproxen in human plasma: Application to a bioequivalence study

“…A critical comparison of different analytical methods for identification and determination of several triptans including SUM has been reviewed by Saka [23]. Like SUM, there are numerous methods for the determination of NAP in biological fluids by a variety of analytical techniques like capillary electrophoresis [24], flow injection chemiluminescence [25], room temperature liquid phosphorimetry [26], electrokinetic capillary chromatography [27], fluorescence spectrometry [28][29][30][31][32], GC-MS [33], HPLC with chemiluminescence [34], fluorescence [33,[35][36][37][38] and UV detection [33,36,[39][40][41][42][43][44][45][46] and LC-MS/MS [46][47][48]. NAP has been determined in human plasma and dried blood spots by LC-MS/MS for pharmacokinetic comparison in the concentration range of 0.5-100 g/mL [47].…”

Comparative bioavailability studies of binary and ternary solid dispersions of Nabumetone in Wistar albino rats

“…HPLC was proved to be a better technology to detect plasma concentration of 6-MNA even in low levels (Al-Momani, 1997). A number of experiments were performed using HPLC to quantify the metabolite in plasma as well as urine (Mikami et al, 2000;Wanwimolruk, 1990;Ray and Day, 1984). Modified HPLC methods were employed for determination of 6-MNA in human plasma (Jang et al, 1995;Kobylińska et al, 2003).…”