A simple, fast and cost-effective method of synthesis of cupric oxide nanoparticle with promising antibacterial potency: Unraveling the biological and chemical modes of action

Synthesis of hybrid copper-chitosan nanoparticles with antibacterial activity against cariogenic <i>Streptococcus mutans </i>

“…Although biological mechanism of bacterial cell killing by the CuNPs is not yet fully understood, the most recent investigations suggest that their activity is due to nascent ions generated from the oxidation of the nanoparticles when they are in the vicinity of cells or organic medium components 3) . The finding indicates that 'particlespecific' effect rather than 'ion-specific' one is responsible for the CuNP action 4) . The antimicrobial activity of CuNPs has been studied against different pathogenic microorganisms, however, no studies have been reported about their activity against cariogenic bacteria.…”

“…In addition, bactericidal activity of CuChNPs is consequence of the bacterial cell damage provoked by the oxidative stress induced by copper. Moreover, CuNP forms complex with organic components of cellular medium that promotes the generation of reactive oxygen species (ROS), which causes membrane lipid per-oxidation and chromosomal DNA degradation 4) . Metallic nanoparticles may also inhibit the activity of glucosyltransferase (GTF) 26) , enzyme that produces glucans that participate in the adhesion of S. mutans to the tooth and favor the bacterial aggregation within a biofilm 27) .…”

Comparative Antibacterial Effects of a Novel Copper and Silver- Based Core/Shell Nanostructure by Sonochemical Method

“…Chakraborty et al evidenced that the antibacterial role of the Cu(II) oxide nanoparticle was a "particle-specific effect" which caused cellular DNA damage through phospho-di-ester bond breakage [26]. Gomes et al demonstrated that Cu-salts were more toxic than Cu-NPs because of the oxidative stress and differential gene expression [27].…”

Formation of Hierarchical CuO Nanostructures on Copper Foil by Chemical Bath Deposition for Applications in Superhydrophobic Surfaces

“…These include solar cells [3], gas and chemical sensors [4][5][6][7], nanofluidics [8], photocatalysis [9][10], superhydrophobic surfaces [11], antimicrobial and antifungal agents [12][13] and electrochemical energy storage applications [14][15][16][17][18][19]. In particular, CuO superhydrophobic surfaces have been gaining interest because they have superior hydrophobicity but are very economical.…”