A simple dual-channel imidazo[1,5-a]pyridine-based fluorescent probe for the discrimination between Cys/Hcy and GSH

A fast-responsive fluorescent probe based on a styrylcoumarin dye for visualizing hydrogen sulfide in living MCF-7 cells and zebrafish

“…In the process of maintaining biological homeostasis, reactive sulfur species (RSS), including hydrogen sulde (H 2 S) and biological mercaptans (Cys, Hcy, and GSH), are essential thiolcontaining molecules for resisting oxidative stress and maintaining the normal physiological function of organisms. [1][2][3] Numerous research works have revealed that H 2 S is considered to be a third endogenous gaseous transmitter aer nitric oxide (NO) and carbon monoxide (CO). [4][5][6] As a vital antioxidant molecule, H 2 S can make an important contribution to the regulation of blood vessels and inhibition of apoptosis when present at an appropriate concentration.…”

Simultaneous Discrimination of Cys/Hcy and GSH With Simple Fluorescent Probe Under a Single-Wavelength Excitation and its Application in Living Cells, Tumor Tissues, and Zebrafish

“…However, owing to the similar structures and reactivities of GSH and Cys/Hcy, simultaneous selective detection of Cys/Hcy and GSH is still a great challenge. Recently, the nitrobenzoxadiazole (NBD) group, having an excellent sensing moiety, has been used to distinguish Cys/Hcy from GSH with dual emission signals in the construction of optical sensors ( Ren et al, 2020b ; Chen et al, 2021b ; Li et al, 2021b ; Zhang et al, 2021b ; Rong et al, 2021 ). Despite these obvious advances, some of the reported NBD-based probes suffer from complex synthesis processes, low sensitivity, and slow response.…”

Copper‐Promoted Direct Decarboxylative C3‐Acylation of Electron‐Rich Indolizines Using α‐Keto Acids

“…[36][37][38][39][40][41][42] As part of our program, we are exploring novel fluorophores for cell imaging. [43][44][45][46][47][48][49][50][51][52][53][54][55] For this purpose, we are interested in the direct synthesis of C-3-acylated indolizines via CÀ H activation. Although similar reactions on indoles have long been known (Scheme 1c), [56] no examples of acylations involving indolizines by the use of α-keto acids have been reported to date.…”

“…As part of our program, we are exploring novel fluorophores for cell imaging [43–55] . For this purpose, we are interested in the direct synthesis of C‐3‐acylated indolizines via C−H activation.…”