A Simple, Cost‐effective, and Environmentally Friendly Method for Determination of Ciprofloxacin in Drugs and Urine Samples Based on Electrogenerated Chemiluminescence

Abstract

Ciprofloxacin is an antibiotic that belongs to the class of drugs known as quinolones and it is frequently used to treat a variety of bacterial infections. The present work aims the development of a simple, cost‐effective, and environmentally friendly method for the determination of ciprofloxacin in drugs and artificial urine samples due to the high importance of this antibiotic for the human health. The proposed method is based on the electrogenerated chemiluminescence (ECL) resulting from the reaction between the ciprofloxacin and the tris(2,2′‐bipyridyl)ruthenium(II) complex. This method exploits a screen‐printed carbon electrode positioned in an ECL cell with capacity to 50 μL of electrolytic solution. The ECL intensity was monitored with the aid of a photodiode. The ECL signal was simultaneously registered to the voltammetric measurements. Under optimized experimental conditions, the ECL method presented a linear response range for ciprofloxacin between 0.5 and 500 μmol L−1 (or 0.0005 and 0.5 mmol L−1). The proposed method presented a detection limit of 0.5 μmol L−1 and it was successfully applied for the ciprofloxacin determination in drugs and artificial urine samples, with good accuracy and precision.

Development and Validation of Novel Analytical Method for the Determination of Particle Size Distribution in Ciprofloxacin Hydrochloride Using Laser-based Particle Size Analyzer

“…Ciprofloxacin Hydrochloride is used to treat a variety of bacterial infections [1,2]. Ciprofloxacin belongs to a class of drugs called quinolone antibiotics [3]. It works by stopping the growth of bacteria.…”