A Simple Approach to Sensor Discovery and Fabrication on Self-Assembled Monolayers on Glass

Abstract

Self-assembled monolayers (SAMs) on glass were used as a platform to sequentially deposit fluorophores and small molecules for ion sensing. The preorganization provided by the surface avoids the need for complex receptor design, allowing for a combinatorial approach to sensing systems based on small molecules. The resulting libraries are easily measured and show varied responses to a series of both cations and anions. This technology is transferable from the macro-to the microscale both via microcontact printing (µCP), where the fluorophore is printed onto a glass surface, and via direct attachment of the fluorophore to microchannel walls. The ease of miniaturization of this technology may make the generation of a wide variety of simple yet efficient microarrays possible.

Design of Fluorescent Materials for Chemical Sensing

“…The selectivity of these systems is not large but their performance is enhanced by the realization of cross reactive sensor arrays. 218 This sensitive monolayers libraries have been used for the fluorescent sensing of inorganic anions in organic solvents, 219 of metal ions in organic solvents 44,219 and water, 220 and for the fabrication of metal ion and luminescent patterns in glass surfaces. 221 Using this approach they have also shown the fabrication of microfluidic devices for optical sensing of metal ions.…”

“…221 Using this approach they have also shown the fabrication of microfluidic devices for optical sensing of metal ions. 219 Moreover, the sensing systems can be fabricated using microcontact printing, a soft lithography technique that permits to easily make controlledsize features down to 100 nm. 219 Recently, the immobilization of a pH sensitive fluorophore (Oregon Green 514) inside of a glass microchannel, has yielded the first monolayer-functionalized microfluidic devices for optical sensing of pH (Fig.…”

The development of a high-throughput/ combinatorial workflow for the study of porous polymer networks

“…20 Due to the success of the HT/C approach in the pharmaceutical industry, it has more recently been applied to material research and development. Examples of material research and development involving the HT/C methodology include 24 sensors, 25 and polymers 26,27 to name a few. In general, HT/C workflows for material development involve the use of robotics to synthesize materials in parallel, HT analytical techniques to rapidly characterize the materials and determine their critical properties of interest, and software to facilitate experimental design, control of robotic instrumentation, and data analysis.…”

Rhodamine‐Based “Turn‐On” Fluorescent Chemodosimeter for Cu(II) on Ultrathin Platinum Films as Molecular Switches

“…This methodology is transferable from the macro-to the microscale through patterning of the monolayer surface and microchannel technologies. [26] The ease of miniaturization on self-assembled systems is promising and will allow expansion of the range of analytes combined with microarray technology.…”