2014
DOI: 10.1002/mrm.25311
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A simple and robust test object for the assessment of isotropic diffusion kurtosis

Abstract: Colloidal dispersions provide a suitable and stable test object for the assessment and reproducibility measurements of kurtosis.

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Cited by 5 publications
(9 citation statements)
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References 50 publications
(79 reference statements)
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“…The “natural” phantoms based on cream and asparagus (12, 13, 22) provide single “untunable” kurtosis parameter value and perish quickly. Synthetic phantoms comprising the polyethylene particle suspensions (23) and most recently suggested microbead impregnated gels (24) are more stable, but still suffer from limited range of provided kurtosis parameters (K app < 0.7) and limited precision owing to microscopic sample inhomogeneity, chemical shift (23), and/or low signal-to-noise ratio (SNR) (short T2) (24). Our recent pilot study (25) proposed the development of novel kurtosis phantoms based on lamellar (amorphous layers) and vesicular (fluid-filled microsacs) phases of liquid crystal systems.…”
Section: Introductionmentioning
confidence: 99%
“…The “natural” phantoms based on cream and asparagus (12, 13, 22) provide single “untunable” kurtosis parameter value and perish quickly. Synthetic phantoms comprising the polyethylene particle suspensions (23) and most recently suggested microbead impregnated gels (24) are more stable, but still suffer from limited range of provided kurtosis parameters (K app < 0.7) and limited precision owing to microscopic sample inhomogeneity, chemical shift (23), and/or low signal-to-noise ratio (SNR) (short T2) (24). Our recent pilot study (25) proposed the development of novel kurtosis phantoms based on lamellar (amorphous layers) and vesicular (fluid-filled microsacs) phases of liquid crystal systems.…”
Section: Introductionmentioning
confidence: 99%
“…The colloidal dispersions reported in Ref. displayed kurtosis values in the range 0 ≤ K coll ≤ 0.62 and while suitable for long‐term use, they do not possess the same relaxation rates as tissue, which would be advantageous for multimodality imaging.…”
Section: Introductionmentioning
confidence: 99%
“…It has been claimed that kurtosis is related to barrier concentration (see, for example, ) and also R2* (see, for example, ) although the fundamental origin of non‐Gaussian diffusion in biological systems is not fully understood. It is not our aim in this paper to investigate the microscopic origin of the diffusion‐weighted MR signal but to create tissue‐mimicking gel phantoms appropriate for DKI with relaxation rates similar to tissue by characterizing the ADCs, kurtosis values, and relaxation times of agar, agarose, and PVA phantoms.…”
Section: Introductionmentioning
confidence: 99%
“…The plot clearly shows that the logarithm of a signal intensity varies linearly with b for the range of values 0 s/mm 2 to 1000 s/mm 2 for all voxels, i.e., we observe no evidence of non-Gaussian diffusion. This is not too surprising as usually a minimum b-value of 1500 s/mm 2 is required to quantify non-Gaussianity [18]. In the waterfall plots brighter colors (yellow)…”
Section: Adc Maps Distribution Of Adc Values and Quality Of Fitmentioning
confidence: 92%