A simple and robust method for broad range screening of hair samples for drugs of abuse using a high-throughput UHPLC-Ion Trap MS instrument

Musile, Giacomo; Mazzola, M.; Shestakova, Ksenia; Savchuk, S. A.; Appolonova, Svetlana A.; Tagliaro, Franco

doi:10.1016/j.jchromb.2020.122263

Cited by 13 publications

(7 citation statements)

References 14 publications

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“…The main challenge of NPS analysis is characterized by the emergence of novel NPS, requiring thus the updating of analytical methods able to detect and quantify a broad amount of compounds from different NPS classes. Considering these issues, many studies have been performed for the development of screening methods to analyze a large number of NPS from keratine matrix using HPLC-MS methods [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34].…”

Section: Discussionmentioning

confidence: 99%

A comprehensive UHPLC–MS/MS screening method for the analysis of 98 New Psychoactive Substances and related compounds in human hair

Nzekoue

Agostini²,

Verboni

et al. 2021

Journal of Pharmaceutical and Biomedical Analysis

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Section: Discussionmentioning

confidence: 99%

A comprehensive UHPLC–MS/MS screening method for the analysis of 98 New Psychoactive Substances and related compounds in human hair

Nzekoue

Agostini²,

Verboni

et al. 2021

Journal of Pharmaceutical and Biomedical Analysis

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“…2 The elderly with psychoactive substance use disorder are increasingly consuming alcohol and other substances. [3][4][5][6] Elderly people are susceptible to AUD for the following reasons; changes in body composition and metabolism, and underlying medical comorbidities. 3 AUD is linked to marked limitations in social, psychological, physical, and cognitive functioning.…”

Section: Introductionmentioning

confidence: 99%

Alcohol Use Disorder and Associated Factors Among Elderly in Ethiopia

Wolde

2023

Subst�Abuse

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Background: The aim of this study was to investigate the magnitude and associated factors of alcohol use disorder among the elderly living in 3 towns in South West Ethiopia. Method: Cross-sectional community-based study was done among 382 elderly people aged 60 or more from February to March 2022 in South West Ethiopia. The participants were selected by a systematic random sampling method. Alcohol use disorder, quality of sleep, cognitive impairment, and depression were assessed by using AUDIT, Pittsburgh Sleep Quality Index, Standardized Mini Mental State Examination, and geriatric depression scale, respectively. Also, suicidal behavior, elder abuse, and other clinical and environmental factors were assessed. The data was entered into Epi Data Manager Version 4.0.2 before being exported to SPSS Version 25 for analysis. A logistic regression model was used, and variables with a P-value less than .05 in the final fitting model were stated as independent predictors of alcohol use disorder (AUD). Result: The magnitude of alcohol use disorder, current alcohol use, and life-time alcohol use among the elderly was 27.5%, 52.4%, and 89.3%, respectively. Also, 7%, 23%, 8.9%, and none of the elderly had nicotine, khat, inhalants, and cannabis use disorder, respectively. Furthermore, AUD was associated with cognitive impairment (AOR, 95% CI; 2.79 (1.47-5.30)), poor sleep quality (AOR, 95% CI; 3.27 (1.23-8.69)), chronic medical illness (AOR, 95% CI; 2.12 (1.20-3.74)), and suicidal ideation (AOR, 95% CI; 5.27 (2.21-12.60)). Conclusion: Problematic alcohol use was higher among the elderly, and cognitive impairment, poor sleep quality, having chronic medical illness, and suicidal ideation were risk factors for AUD. Therefore, community level screening for AUD and comorbid risk factors among this particular age group and managing them is crucial to prevent further complications due to AUD.

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“…In the conventional technique, solidphase extraction (SPE) is a quite famous technique that has been developed for a lot of purposes and combined with the use of high technology, i.e., gas chromatography-mass spectrometry (GC-MS), liquid chromatographymass spectrometry(LC-MS), and liquid chromatographymass spectrometry-mass spectrometry (LC-MS/MS). Solid-phase extraction technique is becoming popular due to the presence of a lot of natural and synthetic adsorbent for being used in the extraction column of solid-phase extraction [12][13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

Detection of Methamphetamine using Nanobentonite as a Novel Solid Phase Extraction Column Matrix Assisted with Gas Chromatography- Mass Spectroscopy

Dalimunthe,

Alfian,

Wirjosentono

et al. 2022

Baghdad Sci.J

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This study was done to evaluate a new technique to determine the presence of methamphetamine in the hair using nano bentonite-based adsorbent as the filler of extraction column. The state of the art of this study was based on the presence of silica in the nano bentonite that was assumed can interact with methamphetamine. The hair used was treated using methanol to extract the presence of methamphetamine, then it was continued by sonicating the hair sample. Qualitative analysis using Marquish reagent was performed to confirm the presence of methamphetamine in the isolate.The hair sample that has been taken in a different period confirmed that this current developing method can be used to analyzed methamphetamine. This method has an average recovery percentage by 104%. This result was also supported by the precision, linearity, LOD and LOQ, i.e. 0.0775; 0.968; 0.00000256 and 0.000000775, respectively.

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A simple and robust method for broad range screening of hair samples for drugs of abuse using a high-throughput UHPLC-Ion Trap MS instrument

Cited by 13 publications

References 14 publications

A comprehensive UHPLC–MS/MS screening method for the analysis of 98 New Psychoactive Substances and related compounds in human hair

A comprehensive UHPLC–MS/MS screening method for the analysis of 98 New Psychoactive Substances and related compounds in human hair

Alcohol Use Disorder and Associated Factors Among Elderly in Ethiopia

Detection of Methamphetamine using Nanobentonite as a Novel Solid Phase Extraction Column Matrix Assisted with Gas Chromatography- Mass Spectroscopy

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