A simple and rapid fluorescent approach for flavonoids sensor based on gold nanoclusters

Peng, Juanjuan; Su, Yaoquan; Huang, Feng-Qing; Zuo, Qing-Ping; Yang, Liqiang; Li, Junyao; Zhao, Lingzhi; Qi, Lian‐Wen

doi:10.1016/j.jcis.2018.12.042

Cited by 25 publications

(10 citation statements)

References 41 publications

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“…It has been reported that thiolate-protected clusters have significant applications in catalysis, − electrochemiluminescence, , organic solar cells, and biomedical fields. − Recently, Ortega et al reported the vibrational properties of thiolate-protected Au NCs, characterized by infrared and Raman spectroscopies . Maran et al reported magnetic resonance (NMR) characterization methods applied to benchmark sizes of NCs, namely Au 25 and chiral Au 38 .…”

Section: Introductionmentioning

confidence: 99%

Protein-Like Large Gold Clusters Based on the ω-Aminothiolate DMAET: Precision Thermal and Reaction Control Leading to Selective Formation of Cationic Gold Clusters in the Critical Size Range, n = 130–144 Gold Atoms

et al. 2019

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The ubiquitous Au 144 (SR) 60 and closely related compounds of ∼29 kDa (core mass) are large monolayer protected clusters (MPC) comprising 144 gold atoms and 60 thiolate ligands (RS groups). Since this cluster family was first identified in 1996, it has served innumerable investigations from physicochemical fundamentals in the quantum "critical size" regime to practical applications in biomedicine, using various phases appropriate to the R-group properties. Very recently, Wu and co-workers achieved an unambiguous determination of the virus-like chiral-icosahedral symmetry of its Au−S core-and surface-structure. Despite these enormous advances, certain practical considerations restricted its applicability. An extraordinary recent development is that ESI-MS allows all the coexisting species in solution to be precisely detected, revolutionizing research on smaller MPCs. The difficult electrospray ionization properties of the critical-size MPCs have so far precluded the full application of ESI-MS methods. Building on the advances by Ishida and co-workers in cationized (quat-terminated) Rgroups, we have recently found a path to tertiary-amino thiolate-protected clusters with characteristic basic properties including pH-controlled ionization of terminal amino groups. Here we report the first extension of these methods beyond the small-cluster domain and into the critical-size regime. In particular, we disclose a precision route to captamine-protected Au 144 (SR) 60 clustersaccompanied by small quantities of its Au 137 and Au 130 byproducts and indications of somewhat larger (plasmonic) speciesthat promises to overcome these challenges due to its amphiphilic nature and solubility in both aqueous and organic phase upon contact with acid or base in the solution. The ESI-MS analysis generates up to a 8+ charge state without any special counterions or ion-pairing agents.

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Section: Introductionmentioning

confidence: 99%

Protein-Like Large Gold Clusters Based on the ω-Aminothiolate DMAET: Precision Thermal and Reaction Control Leading to Selective Formation of Cationic Gold Clusters in the Critical Size Range, n = 130–144 Gold Atoms

et al. 2019

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“…An interesting approach for flavonoids detection was developed by Peng et al in 2019 using a fluorescent gold nanocluster embedded in the structure of bovine serum albumin (BSA) [ 135 ]. The authors proposed a sensing platform based on BSA-AuNCs for the detection of various flavonoids and they determined quercetin in serum and plasma, although with potential interfering of other substances.…”

Section: Optical and Fluorimetric Sensorsmentioning

confidence: 99%

Biosensors and Sensing Systems for Rapid Analysis of Phenolic Compounds from Plants: A Comprehensive Review

2020

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Phenolic compounds are secondary metabolites frequently found in plants that exhibit many different effects on human health. Because of the relevant bioactivity, their identification and quantification in agro-food matrices as well as in biological samples are a fundamental issue in the field of quality control of food and food supplements, and clinical analysis. In this review, a critical selection of sensors and biosensors for rapid and selective detection of phenolic compounds is discussed. Sensors based on electrochemistry, photoelectrochemistry, fluorescence, and colorimetry are discussed including devices with or without specific recognition elements, such as biomolecules, enzymes and molecularly imprinted materials. Systems that have been tested on real matrices are prevalently considered but also techniques that show potential development in the field.

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“…Deionized water (2.5 mL) and GE [various concentrations (0-222 mg mL −1 ) for optimization, 2.5 mL] were added into the aforementioned samples, which were then sonicated for an additional 30 s for the preparation of G-BSA-AuNCs. The final mixed samples of the sonicated solutions were transferred to microwave Teflon tubes, and the microwave oven was adjusted for different reaction temperatures (50, 60, 70, 80, and 90 • C) and different reaction times (5,8,10,12,15, and 20 min), according to an optimization process. The products obtained after the microwave reactions were purified through centrifugation in a 3 K centrifugal membrane at a speed of 8000 rpm for 25 min (with an interval time of 5 min).…”

Section: Preparation and Optimization Of The Mw_bsa-aunc And Mw_g-bsamentioning

confidence: 99%

“…We optimized the synthesis conditions. The final mixtures of sonicated solutions were transferred to microwave Teflon tubes for a microwave reaction at 70 • C (100 W) for different reaction times (5,8,10,12,15, and 20 min). The obtained products were purified.…”

Section: Optimization Of the Microwave Reaction Timementioning

confidence: 99%

“…However, some heavy metal components of QDs have been investigated for potential toxic effects in applications. Gold nanoclusters (AuNCs) have become popular for fluorescent probe applications because of their ultra-small size, easy preparation, and good photostability [8][9][10][11]. Bovine serum albumin (BSA)-modified AuNCs (BSA-AuNCs) have gained attention and popularity in applications of aqueous solutions due to their excellent biocompatibility and abundant functional groups [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Microwave Synthesis of Gold Nanoclusters with Garlic Extract Modifications for the Simple and Sensitive Detection of Lead Ions

2020

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Novel bovine serum albumin (BSA)-gold nanoclusters with garlic extract modifications (mw_G-BSA-AuNCs) were prepared through microwave-assisted rapid synthesis. The modified nanoclusters were characterized and used for the simple and sensitive detection of Pb2+ ions. Both turn-on and turn-off methods were used and compared for Pb2+ ion detection. For Pb2+ ions, the preparation time for the modified nanoclusters was 10 min, and the detection time for the nanoclusters was 6 min. The modified nanoclusters were stable, and their fluorescence intensities changed by less than 10% in 60 days. The detection limit and linear range for the “off-on” method of mw_G-BSA-AuNCs for Pb2+ ion detection were 0.28 and 1–20 nM, respectively. The recoveries of the mw_G-BSA-AuNCs probe used for the detection of the Pb(II) ion in tap water ranged from 93.8% to 102.2%, with an average of 97.1%. The “off-on” method of mw_G-BSA-AuNCs can provide a lower detection limit, higher selectivity, and better recovery than the commonly used “turn-off” methods of mw_BSA-AuNCs for Pb2+ ion detection. The proposed method is superior to other methods proposed from 2018 to 2019 because it can provide a shorter preparation time and a lower detection limit with good selectivity. The microwave-assisted novel compound, mw_G-BSA-AuNCs, can be rapidly synthesized in a green manner and can provide a low detection limit, good selectivity, and a simple and fast reaction for Pb2+ ion detection.

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A simple and rapid fluorescent approach for flavonoids sensor based on gold nanoclusters

Cited by 25 publications

References 41 publications

Protein-Like Large Gold Clusters Based on the ω-Aminothiolate DMAET: Precision Thermal and Reaction Control Leading to Selective Formation of Cationic Gold Clusters in the Critical Size Range, n = 130–144 Gold Atoms

Protein-Like Large Gold Clusters Based on the ω-Aminothiolate DMAET: Precision Thermal and Reaction Control Leading to Selective Formation of Cationic Gold Clusters in the Critical Size Range, n = 130–144 Gold Atoms

Biosensors and Sensing Systems for Rapid Analysis of Phenolic Compounds from Plants: A Comprehensive Review

Microwave Synthesis of Gold Nanoclusters with Garlic Extract Modifications for the Simple and Sensitive Detection of Lead Ions

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