A simple and low-cost portable potentiostat with real-time data sharing for wireless electrochemical analyses

Vidotto, Lourenço Henrique Bittar; Wachholz, Dagwin; Kubota, Lauro T.

doi:10.1016/j.jelechem.2023.117414

Cited by 6 publications

(1 citation statement)

References 24 publications

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“…This means that fewer components are required to create and operate these two-electrode systems. Since open-source three-electrode potentiostats require at least $40 worth of parts, 43 we see enormous potential for two-electrode systems in significantly lowering the costs associated with creating accessible signal readers. To this end, we designed a reader using only one operational amplifier to apply a constant voltage (361.76 ± 0.05 mV) and monitor the current with 0.2 μA resolution and a range up to 211 μA ( Figures 7 a, S19, and S20 ).…”

Section: Resultsmentioning

confidence: 99%

Rapid Electrochemical Flow Analysis of Urinary Creatinine on Paper: Unleashing the Potential of Two-Electrode Detection

Bezinge,

Tappauf,

Richards

et al. 2023

ACS Sens.

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The development of low-cost, disposable electrochemical sensors is an essential step in moving traditionally inaccessible quantitative diagnostic assays toward the point of need. However, a major remaining limitation of current technologies is the reliance on standardized reference electrode materials. Integrating these reference electrodes considerably restricts the choice of the electrode substrate and drastically increases the fabrication costs. Herein, we demonstrate that adoption of two-electrode detection systems can circumvent these limitations and allow for the development of low-cost, paper-based devices. We showcase the power of this approach by developing a continuous flow assay for urinary creatinine enabled by an embedded graphenic two-electrode detector. The detection system not only simplifies sensor fabrication and readout hardware but also provides a robust sensing performance with high detection efficiencies. In addition to enabling high-throughput analysis of clinical urine samples, our two-electrode sensors provide unprecedented insights into the fundamental mechanism of the ferricyanide-mediated creatinine reaction. Finally, we developed a simplified circuitry to drive the detector. This forms the basis of a smart reader that guides the user through the measurement process. This study showcases the potential of affordable capillary-driven cartridges for clinical analysis within primary care settings.

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Section: Resultsmentioning

confidence: 99%