Abstract:Dendritic cells (DCs) control immune responses through their robust antigen presenting activity. Steady-state mouse spleen contains three major DC subsets with distinct functional and phenotypic properties including CD8+ and CD8− conventional DCs (cDCs), and plasmocytoid DCs (pDCs). These subsets are present at a very low frequency (< 4%). Typically, elaborate purification protocols such as FACS-based cell sorting or expansion in culture are needed to obtain enough DCs for subsequent studies. Here, we d… Show more
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