A Simple and Efficient Process for the Synthesis of Novel Heterocycles Containing Benzofuran Moiety Using Thiocarbohydrazide as a Precursor

Baashen, Mohammed

doi:10.1002/jhet.3574

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…In view of the wide variety of biological and pharmacological properties of substituted benzofurans and indoles, several methods were reported so far for the synthesis of these compounds. These include C-H activation through intramolecular annulation method for benzofuran, 32 synthesis of novel heterocycles containing benzofuran motif using thiocarbohydrazide as precursor, 33 Zn catalyzed Sonogashira cyclisation strategy for substituted benzofurans and indoles, 34 C-H amination protocol for substituted indoles 35 and so on. Although there are several reviews on the synthesis of substituted benzofurans and indoles, so far no review is reported yet on MW assisted synthesis of these important compounds.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Microwave Assisted Synthesis of Benzofuran and Indole Derivatives

Anilkumar¹,

Aneeja²,

Afsina³

2021

HETEROCYCLES

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Microwave (MW) assisted syntheses are environment friendly, efficient, rapid and convenient methodology for the synthesis of organic compounds. Benzene ring fused to a five membered ring containing N or O atom exhibits wide range of biological activities.Benzofuran is present in polymers, pharmaceuticals, and bioactive natural products.Benzofuran is significant as insecticides, herbicides, anti-inflammatory and anti-viral agents.Indoles are well known scaffold showing noteworthy activities like anti-tumor, anti-viral, anti-microbial and anti-oxidant. Indole derivatives are valuable moiety in different therapeutically active drug molecules. On account of the biological significance of benzofuran and indole scaffold, this review describes the recent advances in microwave assisted synthesis of benzofurans and indoles, and covers literature from 2012-2020.

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Section: Introductionmentioning

confidence: 99%

Recent Advances in the Microwave Assisted Synthesis of Benzofuran and Indole Derivatives

Anilkumar¹,

Aneeja²,

Afsina³

2021

HETEROCYCLES

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“…Mono-and bis-(thiocarbohydrazones) based on 2-acetylpyridine have antioxidant activity are described [11]. Preparation of thiocarbohydrazones containing benzofuran heterocycles was reported [12]. Thiocarbohydrazone-1-(4-arylidene)-5-(2-oxoindolin-3-ylidene) having antidiabetic properties was explained [13].…”

Section: Introductionmentioning

confidence: 99%

Thiocarbohydrazones Based on Adamantane and Ferrocene as Efficient Corrosion Inhibitors for Hydrochloric Acid Pickling of C-Steel

Sayed

El‐Lateef

2020

Coatings

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N′-(adamantan-2-ylidene)hydrazinecarbothiohydrazide and 2-(ferrocenyl-1-ylidene) hydrazinecarbothiohydrazide are used in coordination and organometallic complexes. The important idea of the research in this paper is the principal to prepare thiocarbohydrazones from the reaction of 2-acetylferrocene (Fe-Th) or 2-adamantanone (Ad-Th) with carbonothioic dihydrazide. The materials were elucidated by elemental analysis and spectral data. The as-prepared compounds were applied as effective corrosion inhibitors for HCl pickling of C-steel. Detailed investigations on electrochemical (open circuit potential (OCP) vs. time, potentiodynamic polarization (PDP), and impedance spectroscopy (EIS)) techniques and surface morphology studies are introduced in this work. Results indicated that Fe-Th could deliver greater inhibition performance than Ad-Th, and the highest protection capacity values of 93.6% (Ad-Th) and 97.9% (Fe-Th) were accomplished at 200 ppm. The adsorption of Ad-Th or Fe-Th additives followed the Langmuir isotherm with both the chemical and the physical adsorption with chemisorption predominance. EIS measurements supported a betterment in the capacitive behavior with the corrosion inhibitors. The inhibitors exhibited a mixed-type behavior as observed from the PDP studies. Field emission scanning electron microscopy (FESEM) and Fourier-transform infrared spectroscopy (FTIR) studies emphasize the occurrence of a protective layer of the as-synthesized organic inhibitors on the C-steel interface. Theoretical studies (density functional theory (DFT) calculations and Monte Carlo (MC) simulations) provide appropriate support for the experimental findings. The existing report provides very significant consequences in formulating and designing novel thiocarbohydrazone inhibitors with high protection efficacy.

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New asymmetric bisthiocarbohydrazones and their mixed ligand nickel(II) complexes: Synthesis, characterization, crystal structure, electrochemical-spectroelectrochemical property, antimicrobial and antioxidant activity

et al. 2021

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A Simple and Efficient Process for the Synthesis of Novel Heterocycles Containing Benzofuran Moiety Using Thiocarbohydrazide as a Precursor

Cited by 3 publications

References 28 publications

Recent Advances in the Microwave Assisted Synthesis of Benzofuran and Indole Derivatives

Recent Advances in the Microwave Assisted Synthesis of Benzofuran and Indole Derivatives

Thiocarbohydrazones Based on Adamantane and Ferrocene as Efficient Corrosion Inhibitors for Hydrochloric Acid Pickling of C-Steel

New asymmetric bisthiocarbohydrazones and their mixed ligand nickel(II) complexes: Synthesis, characterization, crystal structure, electrochemical-spectroelectrochemical property, antimicrobial and antioxidant activity

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