A simple and efficient method for the preparation of 5-hydroxy-3-acyltetramic acids

Abstract

SummaryOxidation of the bisenolates of 3-acyltetramic acid to the corresponding 5-hydroxylated compounds using molecular oxygen is reported. The deprotection of the resulting compounds was also achieved.

One‐Step Synthesis of 3,4‐Diphenyl‐2‐pyrrolinones by Solvent‐Free and Bi2O3‐Catalyzed Approaches and Cytotoxicity Screening Against Glioma Cells

“…The 2-pyrrolinone core is present in several compounds that possess interesting biological activities [1][2][3][4][5][6][7]. Because of this aspect, the synthesis of densely substituted 2pyrrolinone is a theme of ongoing interest, and the development of practical synthetic routes to access this heterocycle demands continuous improvements [8][9][10][11][12][13]. In a subclass of this δ-lactam, the occurrence of two vicinal phenyl substituents is a relevant structural scaffold because it increases the biological effect [1].…”