A simple and convenient method for production of 89Zr with high purity

Production of novel diagnostic radionuclides in small medical cyclotrons

“…The second reaction ( 89 Y(d,2n) 89 Zr), although proven to give high yields both theoretically and experimentally (Sadeghi, Enferadi, and Bakhtiari, 2012 ; Tang et al, 2016 ), requires a relatively high energy deuteron beam since its reaction threshold starts at 5.9 MeV and peaks in the range of 13–17 MeV (Soppera, Bossant, and Cabellos, 2017b ) which excludes most common small medical cyclotrons. Although the GE PETtrace 800 series is capable of producing a deuteron beam with 8.4 MeV and the IBA Cyclone 18/9 is capable of producing deuterons of 9 MeV, it is too low to yield reasonable amounts of 89 Zr.…”

“…In the case of custom made targets, it has been reported that one can achieve higher yields than this, while maintaining high radionuclidic purity of the final product (Sadeghi et al, 2012 ; Tang et al, 2016 ; Alfuraih et al, 2013 ). Custom made yttrium target developments published in recent years (Siikanen et al, 2014 ; Ellison et al, 2016 ), which encompass welding yttrium foils, modifications in yttrium foil thicknesses and water cooling, report applicable designs capable of delivering yields of up to 49 MBq/μAh with maximum currents of 45 μA, and a 90% separation efficiency.…”

Current status and future perspective of radiopharmaceuticals in China

“…1). In addition to these commercial centralized radiopharmacies, large medical institutions equipped with cyclotrons independently produce [ 18 F]FDG and other 11 C-, 15 N-, and 18 F-labeled positron radiopharmaceuticals for clinical research in accordance with the requirements of Regulations on the Preparation of Positron Radiopharmaceuticals in Medical Institutions issued by the NMPA. As the nuclear medicine industry in China continues to grow, more centralized radiopharmacies need to be built to achieve extensive coverage and meet the pace of nuclear medicine development.…”

Production of the next‐generation positron nuclide zirconium‐89 (89Zr) guided by Monte Carlo simulation and its good quality for antibody labeling

“…The current most common route to produce 89 Zr is via cyclotron through the 89 Y(p,n) 89 Zr or 89 Y(d,2n) 89 Zr nuclear reaction. 21,22 The 89 Y(p,n) 89 Zr reaction is more popular because lower proton energies (<14 MeV) are needed. Thus, it is convenient to provide high-yield 89 Zr with an in-house cyclotron using the 89 Y(p,n) 89 Zr nuclear reaction.…”