A simple and accurate dosimetry protocol to estimate activity for hyperthyroidism treatment

Skanjeti, Andrea; Miranti, A.; Yabar, Gabriela Mariam Delgado; Bianciotto, Davide; Trevisiol, Edoardo; Stasi, M.; Podio, Valerio

doi:10.5603/nmr.2015.0004

Cited by 10 publications

(7 citation statements)

References 25 publications

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“…A 1 mL sample was withdrawn at different time intervals to determine the amount of the released drug [ 75 ]. The withdrawn samples were filtered after appropriate dilution and analyzed using a UV spectrophotometer at 269 nm [ 76 ]. The measurements were done in triplicate and the mean ± SD was calculated.…”

Section: Methodsmentioning

confidence: 99%

Synthesis and Antitumor Activity of Doxycycline Polymeric Nanoparticles: Effect on Tumor Apoptosis in Solid Ehrlich Carcinoma

et al. 2020

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Objectives: The aim of this study was to prepare doxycycline polymeric nanoparticles (DOXY-PNPs) with hope to enhance its chemotherapeutic potential against solid Ehrlich carcinoma (SEC). Methods: Three DOXY-PNPs were formulated by nanoprecipitation method using hydroxypropyl methyl cellulose (HPMC) as a polymer. The prepared DOXY-PNPs were evaluated for the encapsulation efficiency (EE%), the drug loading capacity, particle size, zeta potential (ZP) and the in-vitro release for selection of the best formulation. PNP number 3 was selected for further biological testing based on the best pharmaceutical characters. PNP3 (5 and 10 mg/kg) was evaluated for the antitumor potential against SEC grown in female mice by measuring the tumor mass as well as the expression and immunohistochemical staining for the apoptosis markers; caspase 3 and BAX. Results: The biological study documented the greatest reduction in tumor mass in mice treated with PNP3. Importantly, treatment with 5 mg/kg of DOXY-PNPs produced a similar chemotherapeutic effect to that produced by 10 mg/kg of free DOXY. Further, a significant elevation in mRNA expression and immunostaining for caspase 3 and BAX was detected in mice group treated with DOXY-PNPs. Conclusions: The DOXY-PNPs showed greater antitumor potential against SEC grown in mice and greater values for Spearman’s correlation coefficients were detected when correlation with tumor mass or apoptosis markers was examined; this is in comparison to free DOXY. Hence, DOXY-PNPs should be tested in other tumor types to further determine the utility of the current technique in preparing chemotherapeutic agents and enhancing their properties.

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Section: Methodsmentioning

confidence: 99%

Synthesis and Antitumor Activity of Doxycycline Polymeric Nanoparticles: Effect on Tumor Apoptosis in Solid Ehrlich Carcinoma

et al. 2020

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“…Сегодня ассоциации специалистов ядерной медицины во всем мире совершенствуют персонали-зированные подходы к дозиметрически обоснованному расчету терапевтических активностей [1][2][3]. Важно найти оптимальный баланс эффективности и безопасности лечения при условии: 1) минимально необходимого количества сеансов радионуклидной терапии;…”

Section: заключениеunclassified

“…Клетки щитовидной железы активно захватывают йод из крови и используют его для синтеза гормонов. Чем выше функциональная активность щитовидной железы, тем интенсивнее ее клетки захватывают йод из крови [1][2][3][4].…”

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Personalized Approach to Thyrotoxicosis Treatment: The History of Dosimetric Concepts Development

Rumyantsev¹,

Трухин²,

Degtyarev³

2017

Vestn. rentgenol. radiol.

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В последнее десятилетие в ядерной медицине наметилась отчетливая тенденция к совершенствованию дозиметрического планирования радионуклидной терапии. Исторически в ядерной медицине сложился следующий алгоритм индивидуального расчета эффективной терапевтической активности: назначение фиксированной трейсерной активности радиофармпрепарата, изучение его индивидуальной радиобиокинетики с последующим математическим моделированием процессов переноса излучения и расчетом оптимальной терапевтической активности. Данный подход реализует концепцию тераностики в ядерной медицине. Разнообразие существующих протоколов дозиметрического планирования радионуклидной терапии является свидетельством того, что оптимальный алгоритм, учитывающий все индивидуальные параметры человека и параметры излучения (радиобиокинетика в мишени и в организме в целом, объем и функциональное состояние, влияние иных эндогенных факторов), пока не предложен. Разработка робастной модели дозиметрического планирования радионуклидной терапии требует учета всех факторов, независимо и значимо влияющих на формирование эффективной дозы облучения в очагах поражения, с одной стороны, и побочного облучения других органов и тканей, с другой стороны. Ключевые слова: исторический обзор; дозиметрическое планирование; математическое моделирование методом Монте-Карло; радионуклидная терапия.

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“…In the severe Graves' hyperthyroidism, increasing radioiodine dose cannot improve cure rates [20], and thereby individualized dosimetry based on clinical or imaging techniques has been developed for calculation of RAI doses [21]. Nevertheless, there are still issues regarding administration of 131 I activity individualized dosimetry, such as patient selection (in particularly those with ophthalmopathy), prescription algorithms, and the need for adjuvant thyrostatic medication [21][22][23]. The calculated-dose methods showed similar rates of amelioration and hypothyroidism with the cost-saving fixed-dose approach [8,24], there has been limited evidence found in China.…”

Section: Introductionmentioning

confidence: 99%

Predictive factors for the outcomes of Graves’ disease patients with radioactive iodine (131I) treatment

2020

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Although radioactive iodine (131I) treatment (RIT) is recommended as the preferred option for patients with Graves’ disease (GD), the predictive factors for its clinical outcomes are still unclear. In the present study, we aim to investigate the factors influencing the success rate of RIT treatment on primary GD with a calculated dose approach. The thyroid function (hyperthyroidism, euthyroidism or hypothyroidism) was evaluated at least 1 year after RIT, and its relationship with presenting clinical characteristics and pre-RIT parameters was analyzed in 45 patients retrospectively. After RIT, the remission rate was 62.2%, including 13 euthyroidism cases (28.9%) and 15 hypothyroidism cases (33.3%). We found no significant association between the types of thyroid function and age, gender, the 3-h radioactive iodine uptake (RAIU) prior to RIT, or radioactive iodine (131I) dosage. However, a variable 24-h RAIU > 46.31% was found associated with the success rate of RIT. The present study implied that a calculated dose approach for GD is effective, but high failure rates are expected in patients presenting poor 24-h RAIU, particularly those with 24-h RAIU below 46.31%.

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A simple and accurate dosimetry protocol to estimate activity for hyperthyroidism treatment

Abstract: Only EANM algorithm predict quite well, compared to OLINDA/EXM, the required activity to treat hyperthyroid patients.

Cited by 10 publications

References 25 publications

Synthesis and Antitumor Activity of Doxycycline Polymeric Nanoparticles: Effect on Tumor Apoptosis in Solid Ehrlich Carcinoma

Synthesis and Antitumor Activity of Doxycycline Polymeric Nanoparticles: Effect on Tumor Apoptosis in Solid Ehrlich Carcinoma

Personalized Approach to Thyrotoxicosis Treatment: The History of Dosimetric Concepts Development

Predictive factors for the outcomes of Graves’ disease patients with radioactive iodine (131I) treatment

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