A silicone-based support material eliminates interfacial instabilities in 3D silicone printing

Duraivel, S.; Laurent, Dimitri; Rajon, Didier A.; Scheutz, Georg M.; Shetty, Abhishek; Sumerlin, Brent S.; Banks, Scott A.; Bova, Frank J.; Angelini, Thomas E.

doi:10.1126/science.ade4441

Cited by 38 publications

(22 citation statements)

References 36 publications

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“…By altering the above-mentioned parameters, filament diameter could be adjusted. The measured filament diameters were compared with the theoretical values calculated from the fluid continuity equation [18] . This equation takes parameters as volumetric flow rate ( Q ), nozzle speed ( v ) and predicts the diameter of the produced filament ( d ) by following the relationship π(d/2) 2 =Q/v .…”

Section: Resultsmentioning

confidence: 99%

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Nested biofabrication: Matryoshka-inspired Intra-embedded Bioprinting

Alioglu,

Yilmaz,

Singh

et al. 2023

Preprint

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Engineering functional tissues and organs remains a fundamental pursuit in biofabrication. However, the accurate constitution of complex shapes and internal anatomical features of specific organs, including their intricate blood vessels and nerves, remains a significant challenge. Inspired by the Matryoshka doll, we here introduce a new method called ‘Intra-Embedded Bioprinting (IEB),’ building upon existing embedded bioprinting methods. We used a xanthan gum-based material, which served a dual role as both a bioprintable ink and a support bath, due to its unique shear-thinning and self-healing properties. We demonstrated IEB’s capabilities in organ modelling, creating a miniaturized replica of a pancreas using a photocrosslinkable silicone composite. Further, a head phantom and a Matryoshka doll were 3D printed, exemplifying IEB’s capability to manufacture intricate, nested structures. Towards the use case of IEB and employing innovative coupling strategy between extrusion-based and aspiration-assisted bioprinting, we developed a breast tumor model that included a central channel mimicking a blood vessel, with tumor spheroids bioprinted in proximity. Validation using a clinically-available chemotherapeutic drug illustrated its efficacy in reducing the tumor volume via perfusion over time. This method opens a new way of bioprinting enabling the creation of complex-shaped organs with internal anatomical features.

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Section: Resultsmentioning

confidence: 99%

“…This assembly was then directly used to take the micrographs of the filaments using the Zeiss Axio Observer. The filament widths were measured and compared with theoretical filament diameter calculated using the flow continuity equation [18] .…”

Section: Extrusion-based Bioprinting and Its Characterizationmentioning

confidence: 99%

Nested biofabrication: Matryoshka-inspired Intra-embedded Bioprinting

Alioglu,

Yilmaz,

Singh

et al. 2023

Preprint

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“…The appearance of 3D forms in flexible electronics naturally conformed to the logic of industrial upgrading, also marked by the establishment of many different 3D manufacturing approaches, including direct ones (e.g., printing techniques, − photolithographic methods, − molding − ) and indirect ones (e.g., various mechanically-guided assembly methods − ). Printing and photolithographic methods can form a wide range of 3D structures in almost arbitrary geometrical shapes, with feature dimensions ranging from centimeter scales down to micro- and nanoscales. ,, However, it is challenging to simultaneously manufacture 3D architectures and integrated circuits using 3D printing and photolithographic methods because they both suffer from limitations of applicable materials (e.g., not applicable to crystalline semiconductors). While molding methods are not restricted to the accessible types of inks, their achievable structures are constrained to dissolvable or meltable polymeric and metallic materials.…”

Section: Introductionmentioning

confidence: 99%

Mechanically-Guided 3D Assembly for Architected Flexible Electronics

Bo,

Xu,

Yang

et al. 2023

Chem. Rev.

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Architected flexible electronic devices with rationally designed 3D geometries have found essential applications in biology, medicine, therapeutics, sensing/imaging, energy, robotics, and daily healthcare. Mechanically-guided 3D assembly methods, exploiting mechanics principles of materials and structures to transform planar electronic devices fabricated using mature semiconductor techniques into 3D architected ones, are promising routes to such architected flexible electronic devices. Here, we comprehensively review mechanically-guided 3D assembly methods for architected flexible electronics. Mainstream methods of mechanically-guided 3D assembly are classified and discussed on the basis of their fundamental deformation modes (i.e., rolling, folding, curving, and buckling). Diverse 3D interconnects and device forms are then summarized, which correspond to the two key components of an architected flexible electronic device. Afterward, structure-induced functionalities are highlighted to provide guidelines for function-driven structural designs of flexible electronics, followed by a collective summary of their resulting applications. Finally, conclusions and outlooks are given, covering routes to achieve extreme deformations and dimensions, inverse design methods, and encapsulation strategies of architected 3D flexible electronics, as well as perspectives on future applications.

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“…51 This is attributed to their exceptional properties including high thermal resistance, radiation resistance, gas permeability, biocompatibility, and more. 52 Recently, researchers also designed supramolecular silicones with dynamic non-covalent crosslinks. 20,53 The as-prepared surfaces not only show “liquid-like” sliding capability, but also bring damage healing 54 and have other unique functions such as substrate bonding or color patterning.…”

Section: Introductionmentioning

confidence: 99%