A silica-based antioxidant nanoparticle for oral delivery of Camptothecin which reduces intestinal side effects while improving drug efficacy for colon cancer treatment

Nguyen-Trinh, Quynh Nhu; Trinh, Kim Xuyen Thi; Trinh, Nhu‐Thuy; Vo, Toi Van; Li, Nan; Nagasaki, Yukio; Vong, Long Binh

doi:10.1016/j.actbio.2022.02.036

Cited by 15 publications

(13 citation statements)

References 56 publications

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“… 18 Furthermore, nanoparticles and nanotechnology are also used in many other gastrointestinal treatments, such as phototriggered therapy (including photothermal therapy, photoimmunotherapy, and photodynamic therapy), nanopowders, nanoscaffolds, nanogels, and so on. 19 , 20 Nanomedicine has the potential to improve diagnostic tools for gastrointestinal cancers and increase treatment options. 21 However, there is very little available clinical data on nanomedicine applications compared with preclinical data.…”

Section: Introductionmentioning

confidence: 99%

Promising Clinical Applications of Hydrogels Associated With Precise Cancer Treatment: A Review

Wang

Tan

Qin

et al. 2023

Technol Cancer Res Treat

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Gastrointestinal cancer is one of the most malignant tumors with high morbidity and mortality, especially colorectal cancer, which has become the second leading cause of cancer-related deaths worldwide. Targeted drug treatment and precise endoscopic resection can significantly improve the overall survival rate and greatly extend the life span. Promising biomedical applications of hydrogels would represent hopeful therapeutic alternatives for patients with different kinds of diseases, particularly providing precise therapy for cancer patients. Although the intersection field of material science and biomedical science has made tremendous advances, major challenges remain. In this review, the application of hydrogel-based technology in cancer precision medicine is the focus of attention, which is the development trend of multidisciplinary cooperation in the future. First, we provide the current clinical landscape of hydrogel applications, and then we highlight precision oncology, including personalized drug treatment and accurate endoscopic intervention. Finally, we discuss major challenges for their clinical translation that have not yet been overcome and future perspectives on cancer precision medicine.

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Section: Introductionmentioning

confidence: 99%

Promising Clinical Applications of Hydrogels Associated With Precise Cancer Treatment: A Review

Wang

Tan

Qin

et al. 2023

Technol Cancer Res Treat

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“…[12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] Among these strategies, the application of drug delivery systems is attractive because of controlled release of drugs. [15][16][17][18][19][20][21][22][23][24][25][26][27][28] At present, the reported drug delivery systems for the CPT mainly consist of nanoparticlebased drug delivery systems [19][20][21][22][23][24] and LDH-based drug delivery systems. [25][26][27][28][29][30][31] For oral drug delivery system, the safety and stability are of importance.…”

Section: Introductionmentioning

confidence: 99%

“…Unfortunately, the lactone form of CPT exhibits poor water solubility, subsequent low bioavailability, and some adverse effects such as hemorrhagic cystitis, [10,11] thus does not achieve the expected therapeutic outcomes. To address these limitations, various strategies have been tried [12–31] . Among these strategies, the application of drug delivery systems is attractive because of controlled release of drugs [15–28] .…”

Section: Introductionmentioning

confidence: 99%

“…To address these limitations, various strategies have been tried [12–31] . Among these strategies, the application of drug delivery systems is attractive because of controlled release of drugs [15–28] . At present, the reported drug delivery systems for the CPT mainly consist of nanoparticle‐based drug delivery systems [19–24] and LDH‐based drug delivery systems [25–31] .…”

Section: Introductionmentioning

confidence: 99%

“…Among these strategies, the application of drug delivery systems is attractive because of controlled release of drugs [15–28] . At present, the reported drug delivery systems for the CPT mainly consist of nanoparticle‐based drug delivery systems [19–24] and LDH‐based drug delivery systems [25–31] . For oral drug delivery system, the safety and stability are of importance.…”

Section: Introductionmentioning

confidence: 99%

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Eu‐doped ZnAl‐LDH as a Fluorescent Labeling Carrier for the Delivery and Controlled Release of Camptothecin

Qiu

et al. 2022

ChemistrySelect

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Europium doped Zinc‐aluminum layered double hydroxide (Eu‐doped ZnAl‐LDH) as a fluorescent labeling carrier for the delivery and controlled release of camptothecin (CPT) has been studied. X‐ray diffraction (XRD) patterns showed that the basal spacing of the Eu‐doped ZnAl‐LDH intercalated with CPT (2.27 nm) was larger than that of the initial Eu‐doped ZnAl‐LDH (0.88 nm), indicating the successful intercalation of CPT into the Eu‐doped ZnAl‐LDH carrier. X‐ray photoelectron spectroscopy (XPS) suggested that some Eu(III) were reduced to Eu(II) after the intercalation of CPT into the Eu‐doped ZnAl‐LDH. The release of the CPT from drug carrier was carried out in a simulated medium. It was found that the cumulative concentration of the released CPT was exponential with releasing time, and well conformed to the exponential equation: C=A‐Bexp(‐kt). It took 720 minutes (min) for the complete release of CPT from drug carrier. Fluorescent analyses revealed that the fluorescence attributed to the drug delivery system changed from red, blue‐green, to blue emission during delivery and release of CPT, which may be a favorable signal for “detecting” the delivery and release of CPT. Thus, the present Eu‐doped ZnAl‐LDH may be a feasible drug carrier with fluorescent labeling function.

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Green extraction and biological activity of phenolic extracts from cashew nut testa using a combination of enzyme and ultrasound‐assisted treatments

et al. 2023

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BACKGROUND A combination of enzymes and ultrasound treatment was employed to extract bioactive compounds from cashew nut testa, a by‐product of the food industry. The total catechin, flavonoid, and phenolic content of extracts was investigated together with their biological activity. RESULTS Enzyme and ultrasound‐assisted extraction (E‐UAE) was performed by incubation with Viscozyme L (20 mL kg−1 of testa powder, v/w) for 60 min before sonication for 40 min. Ultrasound and enzyme‐assisted extraction (U‐EAE) was carried out using sonication for 40 min before incubation with Viscozyme L (20 mL kg−1 of testa powder) for 60 min. Under appropriate conditions, the total phenolic, flavonoid, catechin, and epigallocatechin gallate content of the extracts from cashew nut testa obtained from a combination method (U‐EAE or E‐UAE) was significantly higher than that obtained using a single method (EAE or UAE). Extracts of cashew nut testa obtained from E‐UAE displayed significantly higher antioxidant and α‐amylase inhibitory activity than those from the U‐EAE. The E‐UAE extract at a concentration of 100 μg mL−1 had a greater impact on the cell viability of MCF‐7 after treatment (22% cell viability) than did the doxorubicin (DOX) at 4 μg mL−1 (39% cell viability), and the E‐UAE extract at 100 μg mL−1 was considered to be safe for healthy cells because the viability of the bovine aerotic endothelial cells treated with this extract was 91%, which was similar to the DOX treatment. CONCLUSION The extract of cashew nut testa obtained from E‐UAE is valuable and promising for the development of anti‐inflammatory therapeutic drugs. © 2023 Society of Chemical Industry.

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A silica-based antioxidant nanoparticle for oral delivery of Camptothecin which reduces intestinal side effects while improving drug efficacy for colon cancer treatment

Cited by 15 publications

References 56 publications

Promising Clinical Applications of Hydrogels Associated With Precise Cancer Treatment: A Review

Promising Clinical Applications of Hydrogels Associated With Precise Cancer Treatment: A Review

Eu‐doped ZnAl‐LDH as a Fluorescent Labeling Carrier for the Delivery and Controlled Release of Camptothecin

Green extraction and biological activity of phenolic extracts from cashew nut testa using a combination of enzyme and ultrasound‐assisted treatments

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