A Silent Nasal Mass with Ophthalmic Presentation

Sarin, Vanita; Singh, Baldev; Prasher, Pawan

doi:10.3109/01676830.2010.522296

Cited by 8 publications

(8 citation statements)

References 8 publications

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“…One cell was karyotypically normal. The remaining 19 cells were characterized by the following abnormal clones: 46,XY, t(12;17)(q24.1;q21) [14]/92,idemx2 [5] (Fig. 1E).…”

Section: Resultsmentioning

confidence: 99%

“…Nasal chondromesenchymal hamartoma is an extraordinarily rare chondrostromal proliferation of the nasal cavity and paranasal sinuses of infants and young children. Approximately 30 cases have been reported in the English-language literature [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. The exact nature of NCMH (hamartomatous versus neoplastic entity) is uncertain.…”

Section: Discussionmentioning

confidence: 99%

“…Nasal chondromesenchymal hamartoma (NCMH) is a benign tumor that occurs predominantly in infants under 1 year of age, although occasional NCMHs affecting older children and adults have been reported [1][2][3][4]. To date, approximately 30 cases of NCMH have been reported in the English-language literature [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. In 1998, McDermott et al [5] proposed the term ''nasal chondromesenchymal hamartoma'' as a distinct clinicopathologic entity typically presenting as a unilateral mass of the nasal cavity and exhibiting a mixed mesenchymal pattern of chondroid and/or osseous islands of tissue with a variably cellular fibrous, myxoid, or giant cell-rich stroma.…”

Section: Introductionmentioning

confidence: 99%

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Translocation T(12;17)(Q24.1;Q21) as the Sole Anomaly in a Nasal Chondromesenchymal Hamartoma Arising in a Patient with Pleuropulmonary Blastoma

et al. 2012

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The identification of recurrent chromosomal abnormalities in benign and malignant mesenchymal neoplasms has provided important pathogenetic insight as well as powerful diagnostic adjuncts. Nasal chondromesenchymal hamartoma (NCMH), an extremely rare benign tumor arising in the sinonasal tract of infants and children, has not been previously subjected to cytogenetic analysis. Histopathologically composed of mixed mesenchymal elements, NCMH exhibits a relatively wide differential diagnosis to include chondromyxoid fibroma, chondroblastoma, aneurysmal bone cyst, fibrous dysplasia, and osteochondromyxoma. An interesting association with pleuropulmonary blastoma has been reported in a small subset of NCMH patients. In the current study, cytogenetic analysis of a NCMH arising in an 11-year-old boy with a past medical history of pleuropulmonary blastoma revealed a novel 12;17 translocation, t(12;17)(q24.1;q21), as the sole anomaly.

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“…One cell was karyotypically normal. The remaining 19 cells were characterized by the following abnormal clones: 46,XY, t(12;17)(q24.1;q21) [14]/92,idemx2 [5] (Fig. 1E).…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Translocation T(12;17)(Q24.1;Q21) as the Sole Anomaly in a Nasal Chondromesenchymal Hamartoma Arising in a Patient with Pleuropulmonary Blastoma

et al. 2012

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“…Proptosis, enophthalmos or impairment of eye movement can be the presenting symptoms or findings in cases with orbital involvement. [2,6,[9][10][11][12][13][14][16][17][18][19] Intracranial extension of the tumor can result in neurologic manifestations. [2,17] Symptoms or signs such as difficulties in respiration or nourishment, epistaxis, rhinorrhea, middle ear effusion can be encountered due to tumor size and site.…”

Section: Discussionmentioning

confidence: 99%

Nasal chondromesenchymal hamartoma: a rare nasal benign tumor

Avcı

Çomoğlu²,

Öztürk³

et al. 2016

Kulak Burun Bogaz Ihtis Derg

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Nasal chondromesenchymal hamartoma (NCMH) is a rare nasal benign tumor, which arises from the nasal cavity or paranasal sinuses. In this article, we present a five-year-old male patient with rhabdomyosarcoma unity in remission that emerged with nasal obstruction. Synchronous diagnosis of pediatric tumors such as pleuropulmonary blastoma in the literature is a remarkable finding. We found a mass within the left nasal cavity originating from superior portion of nasal septum, extending to the olfactory cleft and resected all tumor via endoscopic surgical approach. Histopathological diagnosis revealed that NCMH contained cartilaginous and mesenchymal components. In conclusion, NCMH is a rare surgically treated benign tumor that can be synchronously diagnosed with pleuropulmonary blastoma and should be kept in mind for differential diagnosis of unilateral pediatric nasal mass.

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“…PPB Type III ND Surgical resection No recurrence at 4 months 2. Extension to anterior skull base (18) Sarin, 2010 [ 24 ] India 29 2.5 Y M Right Size: ND 1. Nasal cavity 1.…”

Section: Methodsmentioning

confidence: 99%

Nasal Chondromesenchymal Hamartoma (NCMH): a systematic review of the literature with a new case report

Mason

Navaratnam

Theodorakopoulou

et al. 2015

J of Otolaryngol - Head & Neck Surg

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BackgroundNasal chondromesenchymal hamartoma (NCMH) is a very rare, benign tumour of the sinonasal tract usually presenting in infants. We present a systematic review of NCMH cases alongside a case report of an adult with asymptomatic NCMH.MethodsA systematic review was conducted in accordance with PRISMA guidelines. A PubMed, EMBASE and manual search through references of relevant publications was used to identify all published case-reports of NCMH. Data was collected from each case-report on: patient demographics, laterality, size and location of NCMH, presentation, co-morbidities, investigations, treatment and follow-up.ResultsThe systematic review identified 48 patients (including ours): 33 male, 15 female. Mean age was 9.6 years (range: 1 day–69 years) with the majority aged 1 year or younger at presentation (n = 18). Presentations included: nasal congestion (n = 17), nasal mass (n = 15) and eye signs (n = 12). NCMH also involved the paranasal sinuses (n = 26), orbit (n = 16) and skull-base (n = 14). All patients underwent operative resection of NCMH. A small 2014 case-series found DICER1 mutations in 6 NCMH patients, establishing a link to the DICER1 tumour spectrum.ConclusionsNCMH is a rare cause of nasal masses in young children and adults. In light of the newly established link between NCMH and DICER1 mutations surgeons should be vigilant for associated DICER1 tumours, as NCMH may be the ‘herald tumour’ of this disease spectrum.

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A Silent Nasal Mass with Ophthalmic Presentation

Cited by 8 publications

References 8 publications

Translocation T(12;17)(Q24.1;Q21) as the Sole Anomaly in a Nasal Chondromesenchymal Hamartoma Arising in a Patient with Pleuropulmonary Blastoma

Translocation T(12;17)(Q24.1;Q21) as the Sole Anomaly in a Nasal Chondromesenchymal Hamartoma Arising in a Patient with Pleuropulmonary Blastoma

Nasal chondromesenchymal hamartoma: a rare nasal benign tumor

Nasal Chondromesenchymal Hamartoma (NCMH): a systematic review of the literature with a new case report

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