A significant incidental finding on cone beam computed tomography: multiple myeloma

Biun, J; Lok, Vincent; Koong, Bernard; Huang, Tung-Tsun

doi:10.1111/adj.12695

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…The authors showed that no incidental discoveries of malignancies were observed in their study, indicating that they are relatively unusual findings [ 32 ]. In addition, reports of undiagnosed myeloma discovered incidentally on dental imaging are uncommon [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Osteolytic Lesion of the Maxilla in an Undiagnosed Multiple Myeloma Patient Identified Incidentally by Cone Beam Computed Tomography

et al. 2022

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Patient: Female, 65-year-old Final Diagnosis: Multiple myeloma Symptoms: Palatal lesion Medication: — Clinical Procedure: Biopsy and CBCT • laboratory investigations Specialty: Dentistry Objective: Unusual clinical course Background: Multiple myeloma is a hematological malignancy characterized by monoclonal plasma cell proliferation. Jaw lesions are found in nearly 35% of patients with symptomatic myeloma, and lesions occur in the mandible more often than in the maxilla. However, maxillary or mandibular lesions are rarely found as a primary manifestation of the disease. This report describes a case of a 65-year-old Palestinian woman with lytic lesions in the maxilla due to undiagnosed multiple myeloma identified incidentally on cone beam computed tomography (CBCT). Case Report: A 65-year-old Palestinian woman presented to the Oral Maxillofacial Surgery Clinic with an expansion of the maxilla which was initially thought of as an infection. CBCT imaging revealed diffuse osteolytic lesions involving multiple osseous structures. The patient was biopsied. Histopathological examination was suspicious for plasmacytic neoplasm. She was directly referred to the Hematology Department for further laboratory tests. These included complete blood count, liver function test, bone profile, protein electrophoresis, flow cytometry, and bone marrow biopsy, which were performed to confirm the diagnosis of multiple myeloma. The patient was treated with chemotherapy including zoledronic acid, dexamethasone, bortezomib, and cyclophosphamide. She went into remission for a year but unfortunately died 2 years later. Conclusions: Primary myeloma of the maxilla is a rare presentation. The present report illustrates the role of CBCT imaging supported by a multidisciplinary approach to the diagnosis and management of myeloma. Consequently, it is recommended that dental practitioners be aware of radiographic features and possible oral manifestations to avoid any delay in medical intervention.

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Section: Discussionmentioning

confidence: 99%

Osteolytic Lesion of the Maxilla in an Undiagnosed Multiple Myeloma Patient Identified Incidentally by Cone Beam Computed Tomography

et al. 2022

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“…A dentist cannot elect to read and interpret only part of a bitewing, lateral cephalogram, or OPG 84 . Whilst the possibility of missing major problems is low, serious pathosis can be identified incidentally on dental CBCTs 85,86 . Incidental findings are common with dental CBCTs 87 (Fig.…”

Section: Radiographymentioning

confidence: 99%

“…84 Whilst the possibility of missing major problems is low, serious pathosis can be identified incidentally on dental CBCTs. 85,86 Incidental findings are common with dental CBCTs 87 (Fig. 3).…”

Section: Radiographymentioning

confidence: 99%

Clinical and medico‐legal considerations in endodontics

Johnstone,

Evans

2023

Australian Dental Journal

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Endodontic treatment can be challenging for a number of reasons, including the microscopic nature of the clinical environment, reliance on tactile sensation and lack of direct visualization of the work being performed. Commonly, endodontic patients present with pain and distress, which can exacerbate an already difficult clinical situation. Complications may might arise prior to, or during treatment, despite practising with the utmost care and skill. Preventing and managing these complications can take considerable time and energy, and oftentimes assistance from or referral to more experienced colleagues is required. The aim of this review is to discuss medico‐legal considerations in endodontics, with clinical correlations and a focus on the Australian legal landscape. [Correction added on 18 October 2023, after first online publication: The abstract was amended from a structured to an unstructured abstract.]

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Imaginological characterization of multiple myeloma lesions of the jaws through cone-beam computed tomography

et al. 2019

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A significant incidental finding on cone beam computed tomography: multiple myeloma

Cited by 4 publications

References 22 publications

Osteolytic Lesion of the Maxilla in an Undiagnosed Multiple Myeloma Patient Identified Incidentally by Cone Beam Computed Tomography

Osteolytic Lesion of the Maxilla in an Undiagnosed Multiple Myeloma Patient Identified Incidentally by Cone Beam Computed Tomography

Clinical and medico‐legal considerations in endodontics

Imaginological characterization of multiple myeloma lesions of the jaws through cone-beam computed tomography

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