A “signal-on” chemiluminescence biosensor for thrombin detection based on DNA functionalized magnetic sodium alginate hydrogel and metalloporphyrinic metal-organic framework nanosheets

Lin, Yanna; Sun, Yuanling; Dai, Yuxue; Sun, Wei; Zhu, Xiaodong; Líu, Hao; Han, Rui; Gao, Dandan; Luo, Chuannan; Wang, Xueying

doi:10.1016/j.talanta.2019.120300

Cited by 57 publications

(19 citation statements)

References 54 publications

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“…[290] While many nanosheets, such as PANI, nGO, and rGO, are primarily carbon-based structures, several metallic nanosheets are also in development for use in biosensors. [187,291,292] A new method was devised by Tan et al for producing large amounts of "ultrathin" ternary chalcogenide nanosheets in solution, including Ta 2 NiS 2 and Ta 2 NiSe 2 , with up to 86% of Ta 2 NiS 2 nanosheets being comprised of only a single layer. These "single-layer" nanosheets demonstrated a high capacity for fluorescence quenching and rough morphology (Figure 8D), and a proof-of-concept study was performed to demonstrate their practical use.…”

Section: Nanosheetsmentioning

confidence: 99%

“…[187] Metallic nanosheets have also been combined with DNA-structured assemblies for applications including DNA and thrombin detection. [291,292] In addition to chalcogenide nanosheets, certain transition metal dichalcogenides (TMDs) have been used in their singlelayered nanosheet forms for biosensing applications. One such TMD, tungsten disulfide (WS 2 ), has shown potential as a photoactive material for photoelectrochemical biosensors, recently used in combination with AuNPs and DNA probes to produce a sensor for hydroxymethylated cytosine, a ubiquitous cancer marker.…”

Section: Nanosheetsmentioning

confidence: 99%

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Advances in Biosensors and Diagnostic Technologies Using Nanostructures and Nanomaterials

Welch

Powell

Clevinger

et al. 2021

Adv Funct Materials

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Nanoscale materials have unique properties that make them especially useful for biomedical diagnostic applications. Recent developments in nanoengineering have resulted in increasing use of nanostructures in biosensors. Various types of 0D, 1D, 2D, and 3D nanostructures have been used to improve biosensor sensitivity, selectivity, limit of detection, and time to result, among other metrics. These nanostructures have been integrated into electrochemical, optical, and other biosensors for this purpose. Here, the most recent advances in the use of nanostructured materials in biosensors are described. This includes a discussion of nanoparticles, nanorods, nanofibers, nanopillars, nanowires, nanosheets, indented nanopatterns (nanoholes and nanoslits), nanogaps, nanochannels, nanopores, nanofunctionalized surfaces, and complex hierarchical structures and their unique advantages and applications in biosensors. Clinical applications of these nanobiosensors are also highlighted along with a discussion of the future directions for these materials in diagnostics.

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Section: Nanosheetsmentioning

confidence: 99%

Section: Nanosheetsmentioning

confidence: 99%

Advances in Biosensors and Diagnostic Technologies Using Nanostructures and Nanomaterials

Welch

Powell

Clevinger

et al. 2021

Adv Funct Materials

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“…established a thrombin aptamer 1 functionalized magnetic hydrogel based on the physical interaction between sodium alginate and calcium ions, and used it as a “signal‐on” chemiluminescence biosensor for thrombin detection. [ 71 ] The application of hydrogels in biosensing broadens the design and preparation of biocompatible polymer‐based hydrogels and promotes the application of high‐sensitivity hydrogel sensors.…”

Section: Common Types and Main Functions Of Injectable Hydrogelsmentioning

confidence: 99%

Injectable Nanocomposite Hydrogels for Cancer Therapy

Zong

Guo

et al. 2021

Macromolecular Bioscience

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Hydrogel is a kind of 3D polymer network with strong swelling ability in water and appropriate mechanical and biological properties, which make it feasible to maintain bioactive substances and has promising applications in the fields of biomaterials, soft machines, and artificial tissues. Unfortunately, traditional hydrogels prepared by chemical crosslinking have poor mechanical properties and limited functions, which limit their further application. In recent years, with the continuous development of nanoparticle research, more and more studies have combined nanoparticles with hydrogels to make up for the shortcomings of traditional hydrogels. In this article, the types and functions of hydrogels and nanomaterials are introduced first, as well as the functions and applications of injectable nanocomposite hydrogels (INHs), then the latest progress of INHs for cancer treatment is reviewed, some existing problems are summarized, and the application prospect of NHs is prospected.

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“…Metal-organic frameworks (MOFs) are the practical and novel class of reticular chemicals with periodic network structure. MOFs have direct and indirect extensive applications in many fields including photocatalysts [1], CO2 capture [2], battery materials [3], supercapacitors [4], chemo-thermal therapy [5], separation agents [6,7], biosensors [8], and antibacterial agents [9]. Due to using various organic linker and secondary building units (SBUs), a wide range of these compounds has been synthesized for specific purposes [10⎼13].…”

Section: Graphical Abstract Introductionmentioning

confidence: 99%

Untitled

Sabaghi

Jalaly

Rahsepar

2020

Asian J. Nanosci. Mater.

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Nowadays, metal-organic framework (MOF)-derived porous metal oxide nanoparticles (NPs) has attracted a great attention for remediation of environmental contamination. This work discussed the synthesis approach of the porous and single-phase TiO2 NPs via the thermal treatment of MIL-125 (Ti) at various temperatures. The influences of temperature on the single-phase synthesis and degree of crystallinity of this nanomaterial were investigated. It was revealed that 500 °C was the optimum temperature for the synthesis of anatase phase of nano-titania. The TiO2 NPs produced by heat-treating at 500 °C was found to have a mean particle size of less than 10 nm, specific surface area of 163 m 2 g -1 , and pore volume of 0.374 cm 3 g -1 . The optical properties of the anatase phase of TiO2 were examined and the value of its indirect energy gap (or band gap) was obtained to be 3.08 eV. High specific surface area and porous structure of the anatase TiO2 made it a suitable candidate for the photocatalyst agent. This is due to the fact that it increases the loading capacity of the organic pigments and prolongs the light exposure duration. As-synthesized TiO2 NPs exhibited a high photocatalytic performance for removal of methylene blue (MB), methylene orange (MO) and reactive blue 21 (RB21) organic pigments.

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A “signal-on” chemiluminescence biosensor for thrombin detection based on DNA functionalized magnetic sodium alginate hydrogel and metalloporphyrinic metal-organic framework nanosheets

Cited by 57 publications

References 54 publications

Advances in Biosensors and Diagnostic Technologies Using Nanostructures and Nanomaterials

Advances in Biosensors and Diagnostic Technologies Using Nanostructures and Nanomaterials

Injectable Nanocomposite Hydrogels for Cancer Therapy

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