A side-effect induced by the combination of a demineralized freeze-dried bone allograft and leucocyte and platelet-rich plasma during treatment for large bone cysts: A 4-year follow-up clinical study

Bielecki, Tomasz; Cieślik-Bielecka, A.; Żelawski, Maciej; Mikusek, Wojciech

doi:10.1016/j.transci.2012.06.017

Cited by 13 publications

(13 citation statements)

References 30 publications

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“…Sixty-two articles were eligible for the quantitative systematic review [3, 6, 8–67]. The rest of the articles were excluded, including: 97 articles that were not in English or French [68–164], one randomized clinical trial [165], one prospective study [166], seven case series [167–173], 174 case reports [2, 174–346], 10 basic science articles [5, 347–355], 26 articles that did not discuss UBC treatment [1, 356–380], 17 articles that did not represent clear data on healing [381–397], 18 review articles [4, 398–414], one article that was a reprint [415], three commentary articles [416–418], 36 articles with a sample size smaller than 15 [419–454], and ten articles with possibility of shared cohort [455–464] (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Treatment of unicameral bone cyst: Systematic review and meta analysis

Kadhim

Thacker

Kadhim³

et al. 2014

Journal of Children's Orthopaedics

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PurposeDifferent treatment modalities have been utilized to treat unicameral bone cyst (UBC), but evidence has not been fully described to support one treatment over another and the optimal treatment is controversial. The aim of this quantitative systematic review was to assess the effectiveness of different UBC treatment modalities.MethodsWe utilized Pubmed to isolate retrospective studies on patients with UBC who received any kind of treatment. The included studies needed to have a minimum sample size of 15 patients, and have provided data on radiographic healing outcome.ResultsSixty-two articles were selected for the meta-analysis from a total of 463 articles. The cumulative sample size was 3,211 patients with 3,217 UBC, and male to female ratio was 2.2:1. The summary or pool estimate of methylprednisolone acetate (MPA) injection resulted in a healing rate of (77.4 %) that was comparable to bone marrow injection (77.9 %). A higher healing rate was observed with MPA injection when inner wall disruption was performed. The pool estimate of bone marrow with demineralized bone matrix injection was high (98.7 %). UBC healing rate after surgical curettage was comparable whether autograft or allograft was utilized (90 %). UBC treatment with flexible intramedullary nails without curettage provided almost 100% healing rate, while continuous decompression with cannulated screws provided 89 % healing rate. Conservative treatment indicated a healing rate of 64.2, 95 % CI (26.7–101.8).ConclusionsActive treatment for UBC provided variable healing rates and the outcomes were favorable relative to conservative treatment. Due to the heterogeneity of the studies and reporting bias, the interpretation of these findings should be handled with caution.

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Section: Resultsmentioning

confidence: 99%

Treatment of unicameral bone cyst: Systematic review and meta analysis

Kadhim

Thacker

Kadhim³

et al. 2014

Journal of Children's Orthopaedics

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“…Elongating the soft tissue healing process is performed in two ways. The first way depends on increasing the number and stimulation of stem cells, which secrete TGF- β and IGF to the soft tissue matrix [4–6, 8]. The second and dominant mechanism acts through chemotaxis and macrophage activation, which after the third day takes over platelet function by secreting growth factors.…”

Section: Discussionmentioning

confidence: 99%

“…By concentrating platelets, higher levels of growth factors can be obtained. Amongst others, autologous leukocyte- and platelet-rich plasma (L-PRP) enriched with growth factors may enhance new tissue formation in vitro [1, 2, 6] and in vivo [3, 7]. …”

Section: Introductionmentioning

confidence: 99%

Benefit of Leukocyte- and Platelet-Rich Plasma in Operative Wound Closure in Oral and Maxillofacial Surgery

Cieślik-Bielecka

Glik

Skowroński

et al. 2016

BioMed Research International

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This article reports the influence of an autologous leukocyte- and platelet-rich plasma (L-PRP) injection as a minimally invasive method on supporting wound healing processes after a mandibular odontogenic cystectomy and double mandibular fracture fixation. 113 patients were enrolled into a control group (received no L-PRP injection) and 102 patients were enrolled into an L-PRP group with an oral mucosa incision. 18 patients after a double mandibular fracture were operated on using 2 external submandibular approaches receiving no fluids in the right site (a control group) and an L-PRP injection in the left incision (L-PRP group). Clinical observations showed that the oral mucosa healed faster in patients treated with L-PRP, in comparison to cases where inductive biomaterial was not added. Pain at the L-PRP injection site was relieved within few hours after an operation in patients with double mandibular fractures. However, there were no differences observed in the progression of the healing process. L-PRP possesses inductive properties that could stimulate healing processes and it seems to be one of the most promising methods in the future for the treatment of soft tissue defects.

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“…Some authors [18, 19] have investigated platelet rich plasma and considered eliminating leukocytes from such preparation so as to avoid higher concentrations of pro-inflammatory cytokines that might reduce tissue healing. The study by Anitua et al [12] used PRP that was either rich or poor in leucocytes in order to evaluate whether this could influence tissue healing; however, it appeared that leucocyte concentrations did not interfere with wound healing after oral surgery.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effects of platelet-rich or growth factor-rich plasma on intestinal anastomosis healing in pigs

et al. 2017

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BackgroundThe use of autologous platelet-rich plasma (PRP) and plasma rich in growth factors (PRGF) has been proposed for the treatment of several acute and chronic syndromes, such as corneal epithelial defects and dry eye syndrome, gum bleeding during oral surgery, and in orthopaedic surgery. We hypothesized that PRGF, rather than PRP, could be more effective because of its intrinsic characteristics in promoting the healing of intestinal anastomosis. The purpose of the present study was to evaluate and compare the effects of PRP and PRGF on various parameters of anastomotic healing in a swine model.MethodsEight female pigs were randomly assigned to two groups and subjected to hand sewn jeujuno-jejunal appositional extramucosal anastomoses. For each animal, a total of six anastomoses were performed: two were considered controls and received no treatment, while the remaining four anastomoses were treated with PRP or PRGF of which both were prepared at a platelet concentration that was respectively 3.4-fold and 2.81-fold higher than the original platelet count. In each animal, either PRP or PRGF was used as a treatment, to avoid interference among products. Animals were euthanized after 8 days and the anastomoses were evaluated and compared for the presence of adhesions, anastomotic leakage, bursting pressure, and histological appearance.ResultsThe concentration of platelets in PRP was 3.41-fold higher (range, 3.20–4.24) that the concentration in whole blood, while the concentration in PRGF was 2.81-fold higher (range, 2.89–4.88).The results obtained from the present study highlighted that there are no differences between anastomotic samples treated with either PRP or PRGF preparations, except for a significant increase in epithelization of the intestinal mucosa at the anastomotic site in the PRGF group.ConclusionsBoth PRP and PRGF suspensions should be considered a safe strategy and represent a relatively low-cost technology that is flexible enough to be applied in several therapeutic fields. No true benefit could be proven in our study compared to the no treatment following anastomoses formation, with the exception of enhanced epithelization of the mucosa in the PRGF group.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-017-1102-8) contains supplementary material, which is available to authorized users.

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A side-effect induced by the combination of a demineralized freeze-dried bone allograft and leucocyte and platelet-rich plasma during treatment for large bone cysts: A 4-year follow-up clinical study

Cited by 13 publications

References 30 publications

Treatment of unicameral bone cyst: Systematic review and meta analysis

Treatment of unicameral bone cyst: Systematic review and meta analysis

Benefit of Leukocyte- and Platelet-Rich Plasma in Operative Wound Closure in Oral and Maxillofacial Surgery

Comparison of the effects of platelet-rich or growth factor-rich plasma on intestinal anastomosis healing in pigs

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