A Short‐Term Long‐Chain Triglycerides Infusion Has No Influence on Immune Function of Adult Patients Undergoing Gastrointestinal Surgery

Li, Yong; Ying, Jiaoqian; Zeng, Shan; Shen, Liangfang; Wan, Xiaoping; Li, Xiaorong; Tan, Hui; Pei, Haiping; Zhou, Jun; Shen, Hong

doi:10.1177/0148607107031003167

Cited by 8 publications

(5 citation statements)

References 28 publications

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“…Table 4 reports on immuno-inflammatory and clinical outcomes of trials comparing the use of SOLE in PN with lipid free PN admixtures. Some studies reported either no change or immunostimulatory effects when SOLE was used compared to lipid-free PN admixtures in surgical patients (Dionigi et al, 1985;Monson et al, 1986;Li et al, 2007;Kagawa et al, 2013). Li et al (2007) and Kagawa et al (2012) suggested LE infusion is dosedependent and the infusion rate at 0.09-0.12 g/kg/h does not alter human immune function (Li et al, 2007;Kagawa et al, 2013).…”

Section: Soybean Oil-based Lesmentioning

confidence: 99%

Composition and Functionality of Lipid Emulsions in Parenteral Nutrition: Examining Evidence in Clinical Applications

et al. 2020

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Lipid emulsions (LEs), an integral component in parenteral nutrition (PN) feeding, have shifted from the primary aim of delivering non-protein calories and essential fatty acids to defined therapeutic outcomes such as reducing inflammation, and improving metabolic and clinical outcomes. Use of LEs in PN for surgical and critically ill patients is particularly well established, and there is enough literature assigning therapeutic and adverse effects to specific LEs. This narrative review contrarily puts into perspective the fatty acid compositional (FAC) nature of LE formulations, and discusses clinical applications and outcomes according to the biological function and structural functionality of fatty acids and co-factors such as phytosterols, a-tocopherol, emulsifiers and vitamin K. In addition to soybean oil-based LEs, this review covers clinical studies using the alternate LEs that incorporates physical mixtures combining medium-and long-chain triglycerides or structured triglycerides or the unusual olive oil or fish oil. The Jaded score was applied to assess the quality of these studies, and we report outcomes categorized as per immuno-inflammatory, nutritional, clinical, and cellular level FAC changes. It appears that the FAC nature of LEs is the primary determinant of desired clinical outcomes, and we conclude that one type of LE alone cannot be uniformly applied to patient care.

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Section: Soybean Oil-based Lesmentioning

confidence: 99%

Composition and Functionality of Lipid Emulsions in Parenteral Nutrition: Examining Evidence in Clinical Applications

et al. 2020

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“…Some differences between these studies are the observed changes in insulin and glucose concentrations induced by infusion of intralipid. For example, when systemic insulin increases, an enhancement of systemic cytokines occurs [11–13], whereas if insulin concentrations are kept stable with a hyperinsulinaemic–euglycaemic clamp, no effect on the systemic cytokine response occurs [14, 15]. Thus, as demonstrated in our study, insulin level control is critically important [46].…”

Section: Discussionmentioning

confidence: 79%

“…The effect of NEFAs on inflammation has been investigated especially in models where inflammation is induced experimentally by infusion of endotoxin, with additional NEFA infusion enhancing the systemic cytokine response in some [11–13], but not all studies [14, 15]. Some differences between these studies are the observed changes in insulin and glucose concentrations induced by infusion of intralipid.…”

Section: Discussionmentioning

confidence: 99%

Acute reduction of lipolysis reduces adiponectin and IL-18: evidence from an intervention study with acipimox and insulin

et al. 2013

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Aims/hypothesisLow-grade inflammation is a feature of chronic diseases such as type 2 diabetes and lipodystrophy. It is associated with abdominal adiposity, increased levels of NEFA, hyperinsulinaemia and low adiponectin levels. However, the causal relationship between impaired metabolism and inflammation is not understood. We explored the anti-lipolytic effect of acipimox and insulin on adiponectin and adipocyte-associated cytokines in patients with lipodystrophy.MethodsIn a randomised placebo-controlled crossover design using nine patients with non-diabetic, HIV-associated lipodystrophy, we assessed whether (1) overnight administration of a low dose of acipimox and/or (2) insulin-induced suppression of NEFA flux altered circulating plasma levels of adiponectin, IL-18, TNF-α and IL-6 in the basal condition and in a two-stage euglycaemic–hyperinsulinaemic clamp combined with stable isotopes (insulin infusion rates 20 mU m−2 min−1 and 50 mU m−2 min−1).ResultsInsulin decreased plasma NEFA in a dose-dependent manner (p < 0.0001). Acipimox reduced basal plasma NEFAs and plasma NEFAs during the low-dose insulin infusion compared with placebo (p < 0.0001 for acipimox effect). Plasma adiponectin and plasma IL-18 were reduced during both situations where lipolysis was inhibited (p < 0.0001 for acipimox effect; p < 0.0001 and p < 0.05 for insulin effect on plasma adiponectin and plasma IL-18, respectively). In contrast, plasma IL-6 and plasma TNF-α did not change during low NEFA concentrations.Conclusions/interpretationUsing two different tools to manipulate lipolysis, the present study found that acute inhibition of lipolysis reduces levels of adiponectin and IL-18 in patients with HIV-associated lipodystrophy.

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“…Studies concerning the effect of LCTs on neutrophil function, including phagocytosis, are numerous but results are equivocal and consist of stimulatory, inhibitory as well as neutral effects [7,29–33]. Studies on the use of LCT‐MUFA and VLCT are more sparse.…”

Section: Discussionmentioning

confidence: 99%

Parenteral lipids impair pneumococcal elimination by human neutrophils

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Roelofs

Morsche

et al. 2010

Eur J Clin Investigation

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A Short‐Term Long‐Chain Triglycerides Infusion Has No Influence on Immune Function of Adult Patients Undergoing Gastrointestinal Surgery

Abstract: The regimens of LCT administration may have diverse effects on human immune function in different patient populations. However, LCT emulsion at an appropriate dose and infusion speed does not alter human immune function of adult patients undergoing moderate gastrointestinal surgery.

Cited by 8 publications

References 28 publications

Composition and Functionality of Lipid Emulsions in Parenteral Nutrition: Examining Evidence in Clinical Applications

Composition and Functionality of Lipid Emulsions in Parenteral Nutrition: Examining Evidence in Clinical Applications

Acute reduction of lipolysis reduces adiponectin and IL-18: evidence from an intervention study with acipimox and insulin

Parenteral lipids impair pneumococcal elimination by human neutrophils

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