A short review on liquisolid technology in anti-fungal drugs

Sharma, Shaveta; Kaur, Harpreet; Singh, Jyoti; Yadav, Rahul

doi:10.54037/wjps.2022.100116

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…Clinically affected people display symptoms like abdominal pain, nausea, jaundice and vomiting. The laboratory testing of blood may also reveal increased levels of hepatic transaminases and bilirubin (Sharma and Sharma 2015). The anti-TB drug-related hepatotoxicity is a major reason for increased morbidity and mortality in TB patients undergoing treatment.…”

Section: Need For Use Of Herbal Medicinementioning

confidence: 99%

Herbal Treatment of Tuberculosis

2023

IJAB

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TB is a major threat to public health in the present era. TB as a problem has now become so severe for public health that it has now become a topic of constant debate on international health platforms. Now international health-related organizations have started emphasizing the importance of proper treatment for TB to control and eradicate TB. These programs started getting special attention after the emergence of drug resistance in etiologic agents of TB along with the revelation of the fact the rigorous administration routines of anti-TB drugs are leading to increased cases of hepatotoxicity in patients. This happens due to long dosing regimens of the TB drugs along with high doses being administered to counter drug resistance and eradicate the disease completely. All these issues call for a new perspective on TB medication. Such an alternative is a medication manufactured from herbal extracts. This option kills two birds with one stone. It battles antibiotic resistance while minimizing the chances of liver damage and hepato-toxicity. The herbal extracts have a low cost of manufacturing and do not contain lethal amounts of toxins rendering them safe for consumption even in large amounts. Such useful characteristics of herbal medicine extracts necessitate thorough research to identify useful plants and the parts required to manufacture effective remedies.

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Section: Need For Use Of Herbal Medicinementioning

confidence: 99%

Herbal Treatment of Tuberculosis

2023

IJAB

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Antimicrobial Drugs: Possibilities from Medicinal Plants Part B—Antifungals

Naushad¹,

Türetgen²,

Sugathan³

2023

Sustainable Development and Biodiversity

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Design and evaluation of antifungal vaginal suppository using coconut oil as base for vulvovaginal candidiasis

Mustapha,

Oyedepo,

Akin-Ajani

et al. 2023

Futur J Pharm Sci

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Background The emergence of antimicrobial resistance to antifungals has made vulvovaginal candidiasis a concern. Coconut oil has antimycotic properties that could have a synergistic effect when combined with antifungals. Thus, clotrimazole suppositories were prepared using coconut oil as a base to improve its use and delivery in antimycotic treatment and the suppositories were evaluated for their physicochemical, mechanical, and drug release properties, and the antimycotic effect of clotrimazole and coconut oil was examined singly and in combination, as well as their formulations using the agar-well diffusion method in comparison with polyethylene glycol (PEG), and cocoa butter bases. Using the fusion method, coconut oil was solidified with beeswax (20–50%) to prepare 100 mg clotrimazole suppositories. Surfactants (4% w/w); Tween 20®, Span 20®, sodium lauryl sulphate, and their combinations (3% w/w ratio 1:1 of Tween 20® and Span 20®) were used to improve the rate of drug release from the suppository. Results The suppositories had a pH of 4.1–6.0 and crushing strengths of 0.53 ± 0.07–32.56 ± 5.42 N. Suppositories containing surfactants and those prepared from PEG had significantly (p < 0.05) lower disintegration times ranging from 35 to 90 min than those without surfactants ranging from 305 to 388 min. Drug release (t80) was the fastest from the suppositories containing 40% coconut oil, Tween 20, and PEG. Using the Korsmeyer–Peppas’ model, suppositories made from PEG had a non-Fickian diffusion, while those containing 40% coconut oil, and Tween 20 had a super case II transport mechanism. The combination of clotrimazole and coconut oil gave higher zones of inhibition against Candida species compared to either clotrimazole or coconut oil alone. The formulations had higher antimycotic activities against Candida albicans than Candida krusei and Candida tropicalis. Conclusion The optimized formulation with the desired physicochemical and drug release properties was obtained with coconut oil (40% w/w) solidified with beeswax (50% w/w) as a base. Coconut oil appeared to possess a synergistic antimycotic effect on clotrimazole. Thus, clotrimazole vaginal suppositories with coconut oil as a base in the treatment of vulvovaginal candidiasis showed potential against C. albicans and other Candida species. Graphical abstract

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A short review on liquisolid technology in anti-fungal drugs

Cited by 3 publications

References 3 publications

Herbal Treatment of Tuberculosis

Herbal Treatment of Tuberculosis

Antimicrobial Drugs: Possibilities from Medicinal Plants Part B—Antifungals

Design and evaluation of antifungal vaginal suppository using coconut oil as base for vulvovaginal candidiasis

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