A short peptide protects from age‐onset proteotoxicity
Hassan Elsana,
Reut Bruck‐Haimson,
Huadong Zhu
et al.
Abstract:Aberrant protein aggregation jeopardizes cellular functionality and underlies the development of a myriad of late‐onset maladies including Alzheimer's disease (AD) and Huntington's disease (HD). Accordingly, molecules that mitigate the toxicity of hazardous protein aggregates are of great interest as potential future therapeutics. Here we asked whether a small peptide, composed of five amino acids (5MER peptide) that was derived from the human pro‐inflammatory CD44 protein, could protect model nematodes from t… Show more
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