A Short Oro-Gastric Imipramine Administration in <em>Brucella abortus</em> 2308 Infected Mice Decreases CFU Count at the Spleen; Improves the IFN-γ/IL-6 Ratio; Restores Serotonin Levels in the Hippocampus, Muscular Strength, and Mood
Abstract:Brucellosis infection induces fever, chills, sweats, headache, myalgia, arthralgia, anorexia, fa-tigue, and mood disorders. In mice, it causes a rise in IL-6, TNF-, and IFN-; and reduces sero-tonin and dopamine levels in hippocampus. There is loss in muscle strength and equilibrium and increased anxiety and hopelessness. Imipramine (ImiP) is a tricyclic antidepressant that increases the capacity of macrophages to destroy intracellular microorganisms in vivo. The effect of ImiP was evaluated in Balb/c mice in… Show more
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